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Title: | A Convenient and Facile Synthesis of Naturally Occurring 2,5-Diaryloxazoles |
Authors: | Kumar, Dalip |
Keywords: | Chemistry Synthesis |
Issue Date: | Jul-2012 |
Publisher: | ISCB |
Abstract: | A facile and high yielding synthesis of naturally occurring 2,5-diaryloxazoles including annuloline, balsoxin, texamine and texaline, has been reported. The protocol involves initial reaction of [hydroxy(tosyloxy)iodo] benzene with enolizable ketones to prepare α-tosyloxy ketones, which upon treatment with HMTA and followed by hydrolysis in presence of hydrochloric acid led to α-amino ketones in fairly good yields. Acylation of α-amino ketones produced α-acylamino ketones which upon cyclodehydration in presence of triphenylphosphine and iodine led to 2,5-diaryloxazoles in very good yields . |
URI: | https://www.iscbindia.com/journal.php http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/3049 |
Appears in Collections: | Department of Chemistry |
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