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Title: | Novel bis(indolyl)hydrazide–hydrazones as potent cytotoxic agents |
Authors: | Kumar, Dalip |
Keywords: | Chemistry Bisindoles Hydrazide–hydrazone Anticancer agents Bis(indole) alkaloids |
Issue Date: | Jan-2012 |
Publisher: | Elsiever |
Abstract: | A series of bis(indolyl) hydrazide–hydrazones 5a–n were synthesized and evaluated for their cytotoxicity against selected human cancer cell lines. The reaction of indole-3-carboxaldehyde 2 with indole-3-carbohydrazide 4 in presence of catalytic amount of acetic acid afforded 5a–n in good yields. Among the synthesized bis(indolyl)hydrazide–hydrazones, the compound 5b with N-(p-chlorobenzyl) and bromo substituents was found to be the most potent against multiple cancer cell lines (IC50 = 1.0 μM, MDA-MB-231). The compound 5k exhibited selective cytotoxicity against breast cancer cell line MCF7 (IC50 = 3.1 μM). |
URI: | https://www.sciencedirect.com/science/article/pii/S0960894X11015721?via%3Dihub http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/3050 |
Appears in Collections: | Department of Chemistry |
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