DSpace logo

  1. BITS Pilani Institutional Repository
  2. BITS Faculty Publications
  3. Department of Chemistry
Please use this identifier to cite or link to this item: http://dspace.bits-pilani.ac.in:8080/jspui/xmlui/handle/123456789/3050
Full metadata record
DC FieldValueLanguage
dc.contributor.authorKumar, Dalip-
dc.date.accessioned2021-10-27T04:20:48Z-
dc.date.available2021-10-27T04:20:48Z-
dc.date.issued2012-01-
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0960894X11015721?via%3Dihub-
dc.identifier.urihttp://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/3050-
dc.description.abstractA series of bis(indolyl) hydrazide–hydrazones 5a–n were synthesized and evaluated for their cytotoxicity against selected human cancer cell lines. The reaction of indole-3-carboxaldehyde 2 with indole-3-carbohydrazide 4 in presence of catalytic amount of acetic acid afforded 5a–n in good yields. Among the synthesized bis(indolyl)hydrazide–hydrazones, the compound 5b with N-(p-chlorobenzyl) and bromo substituents was found to be the most potent against multiple cancer cell lines (IC50 = 1.0 μM, MDA-MB-231). The compound 5k exhibited selective cytotoxicity against breast cancer cell line MCF7 (IC50 = 3.1 μM).en_US
dc.language.isoenen_US
dc.publisherElsieveren_US
dc.subjectChemistryen_US
dc.subjectBisindolesen_US
dc.subjectHydrazide–hydrazoneen_US
dc.subjectAnticancer agentsen_US
dc.subjectBis(indole) alkaloidsen_US
dc.titleNovel bis(indolyl)hydrazide–hydrazones as potent cytotoxic agentsen_US
dc.typeArticleen_US
Appears in Collections:Department of Chemistry

Files in This Item:
There are no files associated with this item.
Show simple item record


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.