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Title: | Synthesis and in-vitro anticancer activity of 3,5-bis(indolyl)-1,2,4-thiadiazoles |
Authors: | Kumar, Dalip |
Keywords: | Chemistry Bisindoles 1,2,4-Thiadiazoles Anticancer agents Dimerization Hypervalent iodine regents |
Issue Date: | Oct-2011 |
Publisher: | Elsiever |
Abstract: | A series of 3,5-bis(indolyl)-1,2,4-thiadiazoles were synthesized and evaluated for their cytotoxicity against selected human cancer cell lines. The reaction of indole-3-thiocarboxamide 3 with iodobenzene diacetate underwent oxidative dimerization to give 3,5-bis(indolyl)-1,2,4-thiadiazoles 4a–n. Among the synthesized bis(indoly)-1,2,4-thiadiazoles, the compound 4h with 4-chlorobenzyl and methoxy substituents showed the most potent activity. |
URI: | https://www.sciencedirect.com/science/article/pii/S0960894X11010353?via%3Dihub http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/3052 |
Appears in Collections: | Department of Chemistry |
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