Synthesis and in-vitro anticancer activity of 3,5-bis(indolyl)-1,2,4-thiadiazoles

Please use this identifier to cite or link to this item: http://dspace.bits-pilani.ac.in:8080/jspui/xmlui/handle/123456789/3052

Full metadata record

DC Field	Value	Language
dc.contributor.author	Kumar, Dalip	-
dc.date.accessioned	2021-10-27T04:20:54Z	-
dc.date.available	2021-10-27T04:20:54Z	-
dc.date.issued	2011-10	-
dc.identifier.uri	https://www.sciencedirect.com/science/article/pii/S0960894X11010353?via%3Dihub	-
dc.identifier.uri	http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/3052	-
dc.description.abstract	A series of 3,5-bis(indolyl)-1,2,4-thiadiazoles were synthesized and evaluated for their cytotoxicity against selected human cancer cell lines. The reaction of indole-3-thiocarboxamide 3 with iodobenzene diacetate underwent oxidative dimerization to give 3,5-bis(indolyl)-1,2,4-thiadiazoles 4a–n. Among the synthesized bis(indoly)-1,2,4-thiadiazoles, the compound 4h with 4-chlorobenzyl and methoxy substituents showed the most potent activity.	en_US
dc.language.iso	en	en_US
dc.publisher	Elsiever	en_US
dc.subject	Chemistry	en_US
dc.subject	Bisindoles	en_US
dc.subject	1,2,4-Thiadiazoles	en_US
dc.subject	Anticancer agents	en_US
dc.subject	Dimerization	en_US
dc.subject	Hypervalent iodine regents	en_US
dc.title	Synthesis and in-vitro anticancer activity of 3,5-bis(indolyl)-1,2,4-thiadiazoles	en_US
dc.type	Article	en_US
Appears in Collections:	Department of Chemistry

Files in This Item:

There are no files associated with this item.