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Please use this identifier to cite or link to this item: http://dspace.bits-pilani.ac.in:8080/jspui/xmlui/handle/123456789/3053
Title: One-pot synthesis and anticancer studies of 2-arylamino-5-aryl-1,3,4-thiadiazoles
Authors: Kumar, Dalip
Keywords: Chemistry
1,3,4-Thidiazoles
Anticancer agents
One-pot synthesis
Cancer cell lines
Oxidative cyclization
Issue Date: Apr-2011
Publisher: Elsiever
Abstract: A series of 2-arylamino-5-aryl-1,3,4-thiadiazoles 1a–j were synthesized and screened for their anticancer activity against various human cancer cell lines. The novel one-pot synthesis of 1,3,4-thiadiazoles was achieved by refluxing aryl aldehydes, hydrazine hydrate, and aryl isothiocyanates in methanol followed by oxidative cyclization with ferric ammonium sulfate. The compounds 1g–j with trimethoxyphenyl at the C-5 position displayed extremely potent anticancer activity with at least twofold selectivity (IC50: 4.3–9.2 μM). The nature of substituent on the C-2 arylamino ring may be critical in opting for the selectivity towards a particular cancer cell.
URI: https://www.sciencedirect.com/science/article/pii/S0960894X11002678?via%3Dihub
http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/3053
Appears in Collections:Department of Chemistry

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