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Title: | One-pot synthesis and anticancer studies of 2-arylamino-5-aryl-1,3,4-thiadiazoles |
Authors: | Kumar, Dalip |
Keywords: | Chemistry 1,3,4-Thidiazoles Anticancer agents One-pot synthesis Cancer cell lines Oxidative cyclization |
Issue Date: | Apr-2011 |
Publisher: | Elsiever |
Abstract: | A series of 2-arylamino-5-aryl-1,3,4-thiadiazoles 1a–j were synthesized and screened for their anticancer activity against various human cancer cell lines. The novel one-pot synthesis of 1,3,4-thiadiazoles was achieved by refluxing aryl aldehydes, hydrazine hydrate, and aryl isothiocyanates in methanol followed by oxidative cyclization with ferric ammonium sulfate. The compounds 1g–j with trimethoxyphenyl at the C-5 position displayed extremely potent anticancer activity with at least twofold selectivity (IC50: 4.3–9.2 μM). The nature of substituent on the C-2 arylamino ring may be critical in opting for the selectivity towards a particular cancer cell. |
URI: | https://www.sciencedirect.com/science/article/pii/S0960894X11002678?via%3Dihub http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/3053 |
Appears in Collections: | Department of Chemistry |
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