Please use this identifier to cite or link to this item:
http://dspace.bits-pilani.ac.in:8080/jspui/xmlui/handle/123456789/3057
Title: | Few constraints limit the design of quinone methide-oligonucleotide self-adducts for directing DNA alkylation |
Authors: | Kumar, Dalip |
Keywords: | Chemistry Quinone methide-oligonucleotide DNA alkylation |
Issue Date: | 2011 |
Publisher: | RSC |
Abstract: | Nucleotide sequences minimally containing adenosine, cytosine or guanosine are sufficient to form intrastrand oligonucleotide quinone methide self-adducts reversibly for subsequent alkylation of complementary DNA. The general lack of sequence restrictions should now allow for alkylation of most any target of interest although reaction is most efficient when the self-adducts contain guanine residues and do not form hairpin structures. |
URI: | https://pubs.rsc.org/en/content/articlelanding/2011/cc/c0cc03317k http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/3057 |
Appears in Collections: | Department of Chemistry |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.