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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kumar, Dalip | - |
dc.date.accessioned | 2021-10-27T04:21:12Z | - |
dc.date.available | 2021-10-27T04:21:12Z | - |
dc.date.issued | 2010-03 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0223523409006679?via%3Dihub | - |
dc.identifier.uri | http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/3058 | - |
dc.description.abstract | A series of 4-(3′-indolyl)oxazole congeners have been synthesized and studied for their cytotoxicity against six cancer cell lines. Reaction of 3-acetyl-1′-benzenesulfonylindole with [hydroxy(tosyloxy)iodo]benzene afforded pure 3-tosyloxyacetyl-1′-benzenesulfonylindole. Microwave-accelerated neat reaction of 3-tosyloxyacetyl-1-benzenesulfonylindole with amides resulted in the exclusive formation of 4-(1′-benzenesulfonylindol-3′-yl)-2-substituted oxazoles (4) in very good yield. Treatment of 4 with aqueous sodium hydroxide under refluxing conditions afforded pure 4-(3′-indolyl)-2-substituted oxazoles (5) in excellent yield. The 4-(3′-indolyl)oxazoles 5d and 11 were found to be most cytotoxic and selective against various cancer cell lines. Compounds 5g, 5j and 5l showed moderate anticancer activity. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsiever | en_US |
dc.subject | Chemistry | en_US |
dc.subject | 2,4-Disubstituted oxazoles | en_US |
dc.subject | 4-(3′-Indolyl)oxazoles | en_US |
dc.subject | Anticancer activity | en_US |
dc.subject | Amides | en_US |
dc.subject | α-Tosyloxy ketones | en_US |
dc.title | An expeditious synthesis and anticancer activity of novel 4-(3′-indolyl)oxazoles | en_US |
dc.type | Article | en_US |
Appears in Collections: | Department of Chemistry |
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