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Title: | An efficient synthesis and biological study of novel indolyl-1,3,4-oxadiazoles as potent anticancer agents |
Authors: | Kumar, Dalip |
Keywords: | Chemistry 1,3,4-Oxadiazole Solvent-free Hypervalent iodine Anticancer agent Selective cytotoxicity |
Issue Date: | 1-Aug-2009 |
Publisher: | Elsiever |
Abstract: | A facile, convenient and high yielding synthesis of a series of novel 5-(3′-indolyl)-2-(substituted)-1,3,4-oxadiazoles from readily available starting materials has been described. The key step of this protocol is oxidative cyclization of N-acylhydrazones 1 using [bis(trifluoroacetoxy)iodo]benzene under solvent-free condition. The 5-(3′-indolyl)-2-(substituted)-1,3,4-oxadiazoles were screened for their in vitro anticancer activity against various human cancer cell lines. Compounds 3c, 3d and 3j exhibited potent cytotoxicity (IC50 ∼1 μM) and selectivity against human cancer cell lines. |
URI: | https://www.sciencedirect.com/science/article/pii/S0960894X09004594?via%3Dihub http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/3064 |
Appears in Collections: | Department of Chemistry |
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