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Title: | Synthesis and anticancer activities of novel 3,5-disubstituted-1,2,4-oxadiazoles |
Authors: | Kumar, Dalip |
Keywords: | Chemistry Synthesis Anticancer |
Issue Date: | May-2009 |
Publisher: | Elsiever |
Abstract: | A series of 3,5-disubstituted-1,2,4-oxadiazoles were synthesized and evaluated for their in vitro anti-proliferative activities against various cancer cell lines. Formation of 1,2,4-oxadiazole ring was accomplished by the reaction of amidoxime with carboxylic acids. The in vitro cytotoxic effects of 3,5-disubstituted-1,2,4-oxadiazoles have been demonstrated across a wide array of tumor cell types and a few compounds exhibited specificity towards pancreatic (3f, 3h, 3j, and 3k) and prostate (3n) cancer cells. Among the prepared 3,5-disubstituted-1,2,4-oxadiazoles, compound 3n is the most selective (>450-fold) and compound 3p is the most cytotoxic (10 nM) against prostate cancer cell lines. |
URI: | https://www.sciencedirect.com/science/article/pii/S0960894X09004375?via%3Dihub http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/3067 |
Appears in Collections: | Department of Chemistry |
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