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Title: | A facile and regioselective synthesis of 1,4-disubstituted 1,2,3-triazoles using click chemistry |
Authors: | Kumar, Dalip |
Keywords: | Chemistry α-Tosyloxy ketones 1,4-Disubstituted-1,2,3-triazoles click chemistry Nitrogen heterocycles Copper iodide |
Issue Date: | May-2009 |
Publisher: | Elsiever |
Abstract: | The reaction of α-tosyloxy ketones, sodium azide, and terminal alkynes in presence of copper(I) in aqueous polyethylene glycol afforded regioselectively 1,4-disubstituted 1,2,3-triazoles in good yield at ambient temperature. The one-pot exclusive formation of 1,4-disubstituted 1,2,3-triazoles involves in situ formation of α-azido ketones, followed by cycloaddition reaction with terminal alkyne. The generality of this one-pot method was demonstrated by synthesizing an array of diverse 1,4-disubstituted 1,2,3-triazoles. |
URI: | https://www.sciencedirect.com/science/article/pii/S0040403909003670?via%3Dihub http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/3068 |
Appears in Collections: | Department of Chemistry |
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