A facile and regioselective synthesis of 1,4-disubstituted 1,2,3-triazoles using click chemistry

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DC Field	Value	Language
dc.contributor.author	Kumar, Dalip	-
dc.date.accessioned	2021-10-27T04:21:51Z	-
dc.date.available	2021-10-27T04:21:51Z	-
dc.date.issued	2009-05	-
dc.identifier.uri	https://www.sciencedirect.com/science/article/pii/S0040403909003670?via%3Dihub	-
dc.identifier.uri	http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/3068	-
dc.description.abstract	The reaction of α-tosyloxy ketones, sodium azide, and terminal alkynes in presence of copper(I) in aqueous polyethylene glycol afforded regioselectively 1,4-disubstituted 1,2,3-triazoles in good yield at ambient temperature. The one-pot exclusive formation of 1,4-disubstituted 1,2,3-triazoles involves in situ formation of α-azido ketones, followed by cycloaddition reaction with terminal alkyne. The generality of this one-pot method was demonstrated by synthesizing an array of diverse 1,4-disubstituted 1,2,3-triazoles.	en_US
dc.language.iso	en	en_US
dc.publisher	Elsiever	en_US
dc.subject	Chemistry	en_US
dc.subject	α-Tosyloxy ketones	en_US
dc.subject	1,4-Disubstituted-1,2,3-triazoles	en_US
dc.subject	click chemistry	en_US
dc.subject	Nitrogen heterocycles	en_US
dc.subject	Copper iodide	en_US
dc.title	A facile and regioselective synthesis of 1,4-disubstituted 1,2,3-triazoles using click chemistry	en_US
dc.type	Article	en_US
Appears in Collections:	Department of Chemistry

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