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Title: | Greener and Expeditious Synthesis of 1,4-Disubstituted 1,2,3-Triazoles from Terminal Acetylenes and in situ Generated α-Azido Ketones |
Authors: | Kumar, Dalip |
Keywords: | Chemistry 1,2,3-triazoles α-bromo ketones Click chemistry α-azido ketones |
Issue Date: | 2009 |
Publisher: | Thieme |
Abstract: | A convenient and mild protocol for the one-pot regioselective synthesis of 1,4-disubstituted 1,2,3-triazoles in aqueous PEG 400 has been reported. The methodology involves the one-pot reaction of α-bromo ketones, sodium azide, and terminal acetylenes catalyzed by Cu(I) in aqueous PEG 400 at room temperature. Prominent features of our approach are mild reaction conditions, use of readily available α-bromo compounds, aqueous PEG 400 as a benign reaction medium, avoiding the isolation of labile α-azido ketones, simple workup, and good yields. |
URI: | https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0028-1087556 http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/3069 |
Appears in Collections: | Department of Chemistry |
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