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http://dspace.bits-pilani.ac.in:8080/jspui/handle/123456789/3163| Title: | One-Pot Synthesis of Chiral Tetracyclic Dibenzo[ b, f][1,4]oxazepine-Fused 1,2-Dihydropyridines (DHPs) under Metal-Free Conditions |
| Authors: | Kumar, Indresh |
| Keywords: | Chemistry Catalysts Oxidation Reaction products |
| Issue Date: | Jun-2018 |
| Publisher: | ACS |
| Abstract: | An efficient protocol for the catalytic asymmetric synthesis of new dibenzo[b,f][1,4]-oxazepine-fused 1,2-dihydropyridines (DHPs) has been described under metal-free conditions. This reaction proceeds through proline-catalyzed direct Mannich/cyclization between seven-membered dibenzo[b,f][1,4]-oxazepine-imines and aqueous glutaraldehyde, followed by IBX-mediated site-selective dehydrogenative oxidation in one-pot operation with high yields (up to 92%) and excellent enantioselectivity (up to >99:1 er). |
| URI: | https://pubs.acs.org/doi/10.1021/acs.joc.8b01232 http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/3163 |
| Appears in Collections: | Department of Chemistry |
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