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dc.contributor.authorKumar, Indresh-
dc.date.accessioned2021-10-27T04:27:27Z-
dc.date.available2021-10-27T04:27:27Z-
dc.date.issued2018-
dc.identifier.urihttps://pubs.rsc.org/en/content/articlelanding/2018/ra/c8ra01637b-
dc.identifier.urihttp://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/3164-
dc.description.abstractAn efficient sequential multi-component method for the synthesis of N-arylpyrrole-3-carbaldehydes has been developed. This reaction involved a proline-catalyzed direct Mannich reaction-cyclization sequence between succinaldehyde and in situ generated Ar/HetAr/indolyl-imines, followed by IBX-mediated oxidative aromatization in one-pot operation. The practical utility of this procedure is shown at gram-scale and the synthesis of diverse bioactive fused heterocyclic scaffolds such as pyrroloquinoline, pyrrolo-oxadiazole, dihydro pyrroloquinoline, and pyrrolo-phenanthridine.en_US
dc.language.isoenen_US
dc.publisherRSCen_US
dc.subjectChemistryen_US
dc.subjectMulticomponent reactionen_US
dc.subjectHeterocyclesen_US
dc.subjectPyrrole-3-carbaldehydesen_US
dc.titleOne-pot sequential multicomponent reaction between in situ generated aldimines and succinaldehyde: facile synthesis of substituted pyrrole-3-carbaldehydes and applications towards medicinally important fused heterocyclesen_US
dc.typeArticleen_US
Appears in Collections:Department of Chemistry

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