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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Kumar, Indresh | - |
| dc.date.accessioned | 2021-10-27T04:27:27Z | - |
| dc.date.available | 2021-10-27T04:27:27Z | - |
| dc.date.issued | 2018 | - |
| dc.identifier.uri | https://pubs.rsc.org/en/content/articlelanding/2018/ra/c8ra01637b | - |
| dc.identifier.uri | http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/3164 | - |
| dc.description.abstract | An efficient sequential multi-component method for the synthesis of N-arylpyrrole-3-carbaldehydes has been developed. This reaction involved a proline-catalyzed direct Mannich reaction-cyclization sequence between succinaldehyde and in situ generated Ar/HetAr/indolyl-imines, followed by IBX-mediated oxidative aromatization in one-pot operation. The practical utility of this procedure is shown at gram-scale and the synthesis of diverse bioactive fused heterocyclic scaffolds such as pyrroloquinoline, pyrrolo-oxadiazole, dihydro pyrroloquinoline, and pyrrolo-phenanthridine. | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | RSC | en_US |
| dc.subject | Chemistry | en_US |
| dc.subject | Multicomponent reaction | en_US |
| dc.subject | Heterocycles | en_US |
| dc.subject | Pyrrole-3-carbaldehydes | en_US |
| dc.title | One-pot sequential multicomponent reaction between in situ generated aldimines and succinaldehyde: facile synthesis of substituted pyrrole-3-carbaldehydes and applications towards medicinally important fused heterocycles | en_US |
| dc.type | Article | en_US |
| Appears in Collections: | Department of Chemistry | |
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