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http://dspace.bits-pilani.ac.in:8080/jspui/xmlui/handle/123456789/3175| Title: | Highly enantioselective [4+2] annulation via organocatalytic Mannich-reductive cyclization: one-pot synthesis of functionalized piperidines |
| Authors: | Kumar, Indresh |
| Keywords: | Chemistry Enantioselective [4+2] Organocatalytic |
| Issue Date: | 2013 |
| Publisher: | RSC |
| Abstract: | A new method for one-pot synthesis of 2,3-substituted piperidine from N-PMP aldimine and aqueous glutaraldehyde via formal [4+2] cycloaddition is reported. This reaction involves organocatalytic direct Mannich reaction–reductive cyclization with high yields (up to 90%) and excellent enantioselectivities (up to >99%). The practicability of this method is also shown at a gram scale as well as through the synthesis of functionalized (−)-anabasine |
| URI: | https://pubs.rsc.org/en/content/articlelanding/2013/cc/c3cc42431f http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/3175 |
| Appears in Collections: | Department of Chemistry |
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