Highly enantioselective [4+2] annulation via organocatalytic Mannich-reductive cyclization: one-pot synthesis of functionalized piperidines

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DC Field	Value	Language
dc.contributor.author	Kumar, Indresh	-
dc.date.accessioned	2021-10-27T04:27:59Z	-
dc.date.available	2021-10-27T04:27:59Z	-
dc.date.issued	2013	-
dc.identifier.uri	https://pubs.rsc.org/en/content/articlelanding/2013/cc/c3cc42431f	-
dc.identifier.uri	http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/3175	-
dc.description.abstract	A new method for one-pot synthesis of 2,3-substituted piperidine from N-PMP aldimine and aqueous glutaraldehyde via formal [4+2] cycloaddition is reported. This reaction involves organocatalytic direct Mannich reaction–reductive cyclization with high yields (up to 90%) and excellent enantioselectivities (up to >99%). The practicability of this method is also shown at a gram scale as well as through the synthesis of functionalized (−)-anabasine	en_US
dc.language.iso	en	en_US
dc.publisher	RSC	en_US
dc.subject	Chemistry	en_US
dc.subject	Enantioselective [4+2]	en_US
dc.subject	Organocatalytic	en_US
dc.title	Highly enantioselective [4+2] annulation via organocatalytic Mannich-reductive cyclization: one-pot synthesis of functionalized piperidines	en_US
dc.type	Article	en_US
Appears in Collections:	Department of Chemistry

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