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http://dspace.bits-pilani.ac.in:8080/jspui/handle/123456789/3178| Title: | An organocatalytic direct Mannich–cyclization cascade as [3+2] annulation: asymmetric synthesis of 2,3-substituted pyrrolidines |
| Authors: | Kumar, Indresh |
| Keywords: | Chemistry Organocatalytic Mannich–cyclization Pyrrolidines |
| Issue Date: | 2012 |
| Publisher: | RSC |
| Abstract: | A new method for asymmetric synthesis of 2,3-substituted pyrrolidines from N-PMP aldimines and succinaldehyde via formal [3+2] cycloaddition is reported. This reaction involves proline catalyzed direct Mannich reaction and acid catalyzed reductive cyclization with high yields (up to 78%) and excellent enantioselectivities (up to >99%). |
| URI: | https://pubs.rsc.org/en/content/articlelanding/2012/cc/c2cc33103a http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/3178 |
| Appears in Collections: | Department of Chemistry |
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