An organocatalytic direct Mannich–cyclization cascade as [3+2] annulation: asymmetric synthesis of 2,3-substituted pyrrolidines

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DC Field	Value	Language
dc.contributor.author	Kumar, Indresh	-
dc.date.accessioned	2021-10-27T04:28:07Z	-
dc.date.available	2021-10-27T04:28:07Z	-
dc.date.issued	2012	-
dc.identifier.uri	https://pubs.rsc.org/en/content/articlelanding/2012/cc/c2cc33103a	-
dc.identifier.uri	http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/3178	-
dc.description.abstract	A new method for asymmetric synthesis of 2,3-substituted pyrrolidines from N-PMP aldimines and succinaldehyde via formal [3+2] cycloaddition is reported. This reaction involves proline catalyzed direct Mannich reaction and acid catalyzed reductive cyclization with high yields (up to 78%) and excellent enantioselectivities (up to >99%).	en_US
dc.language.iso	en	en_US
dc.publisher	RSC	en_US
dc.subject	Chemistry	en_US
dc.subject	Organocatalytic	en_US
dc.subject	Mannich–cyclization	en_US
dc.subject	Pyrrolidines	en_US
dc.title	An organocatalytic direct Mannich–cyclization cascade as [3+2] annulation: asymmetric synthesis of 2,3-substituted pyrrolidines	en_US
dc.type	Article	en_US
Appears in Collections:	Department of Chemistry

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