A facile Garratt–Braverman cyclization route to intercalative DNA-binding bis-quinones

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DC Field	Value	Language
dc.contributor.author	Addy, Partha Sarathi	-
dc.date.accessioned	2021-11-11T10:55:28Z	-
dc.date.available	2021-11-11T10:55:28Z	-
dc.date.issued	2012-01-04	-
dc.identifier.uri	https://www.sciencedirect.com/science/article/pii/S0040403911017515	-
dc.identifier.uri	http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/3309	-
dc.description.abstract	Bispropargyl ethers (both symmetrical and non-symmetrical) equipped with 1,4-dimethoxyaryl groups were synthesized. Under strongly basic conditions (KOBut/toluene/reflux), these ethers underwent Garratt–Braverman type cyclization to the tetramethoxy bi-aryl systems in high yields presumably via the bisallenes. The products could be successfully converted to the bis-quinones via CAN-mediated demethylation cum oxidation. This two-step protocol offers a simple route to bis-quinones, connected by C1–C2′ bonds, in good yields. Fluorescence based EB-displacement assay, CD spectroscopy and viscosity measurements confirmed the DNA-binding ability of the synthesized quinones via intercalation.	en_US
dc.language.iso	en	en_US
dc.publisher	Elsiever	en_US
dc.subject	Chemistry	en_US
dc.subject	Garratt–Braverman	en_US
dc.subject	DNA-binding	en_US
dc.title	A facile Garratt–Braverman cyclization route to intercalative DNA-binding bis-quinones	en_US
dc.type	Article	en_US
Appears in Collections:	Department of Chemistry

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