Indazolone-Assisted Sequential ortho-Alkenylation-Oxidative Aza-Michael Addition of 1-Arylindazolone Using Acrylates Under Ru(II) Catalysis

Abstract

A one-pot annulation of 1-arylindazolones and acrylates is achieved through Ru(II)-catalyzed sequential ortho-alkenylation followed by oxidative intramolecular aza-Michael addition reaction to deliver substituted indazolo[1,2-a]indazolylidenes in good-to-excellent yields. The strategy showcased high functional group tolerance and the directing group ability of indazolone moiety was established for Csp2-H bond activation.