Quinine bis-conjugates with quinoloneantibiotics and peptides: synthesis and antimalarial bioassay

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DC Field	Value	Language
dc.contributor.author	Bajaj, Kiran	-
dc.date.accessioned	2021-11-11T11:23:36Z	-
dc.date.available	2021-11-11T11:23:36Z	-
dc.date.issued	2012	-
dc.identifier.uri	https://pubs.rsc.org/en/content/articlelanding/2012/OB/c2ob26439k	-
dc.identifier.uri	http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/3505	-
dc.description.abstract	Benzotriazole-mediated syntheses led to novel bis-conjugates of quinine with quinolone antibiotics and amino acid linkers which were successfully prepared by two alternative routes with excellent yields and retention of chirality. These bis conjugates retain in vitro antimalarial activity with IC50 values ranging from 12 to 207 nM, similar to quinine itself.	en_US
dc.language.iso	en	en_US
dc.publisher	RSC	en_US
dc.subject	Chemistry	en_US
dc.subject	Quinine bis-conjugates	en_US
dc.subject	Quinoloneantibiotics	en_US
dc.subject	Peptides	en_US
dc.subject	Synthesis	en_US
dc.subject	Antimalarial bioassay	en_US
dc.title	Quinine bis-conjugates with quinoloneantibiotics and peptides: synthesis and antimalarial bioassay	en_US
dc.type	Article	en_US
Appears in Collections:	Department of Chemistry

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