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Title: | Efficient Syntheses of Thiadiazole Peptides |
Authors: | Bajaj, Kiran |
Keywords: | Chemistry High-performance liquid chromatography Peptides and proteins Electromagnetic radiation |
Issue Date: | 9-Aug-2010 |
Publisher: | ACS |
Abstract: | Novel N-(Cbz-aminoacyl)thiosemicarbazides 3a−c were cyclized by treatment with sulfuric acid to give 1,3,4-thiadiazoles 4a−c. Compounds 4a−c reacted with N-(Cbz-aminoacyl)- and -dipeptidoylbenzotriazoles to afford chirally pure 1,3,4-thiadiazol-2-yl-substituted amino acids 6a−c and dipeptides 7a−c. |
URI: | https://pubs.acs.org/doi/abs/10.1021/jo100922c http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/3507 |
Appears in Collections: | Department of Chemistry |
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