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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Bajaj, Kiran | - |
dc.date.accessioned | 2021-11-11T11:24:28Z | - |
dc.date.available | 2021-11-11T11:24:28Z | - |
dc.date.issued | 2005-07-01 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0968089605003160?via%3Dihub | - |
dc.identifier.uri | http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/3513 | - |
dc.description.abstract | Variety of N-(4-phenyl-3-(2′,3′,4′(un)substituted phenyl)thiazol-2(3H)-ylidene)-2,4(un)substituted acridin-9-amine (4a–o) and 1-[(2,4-(un)substituted acridin-9-yl)-3-(4-phenyl-3-(2′,3′,4′(un)substituted phenyl)thiazol-2(3H)-ylidene)]isothiourea (5a–h) derivatives have been synthesized by condensation of 4-phenyl-3-(2′,3′,4′(un)substituted phenyl)thiazol-2(3H)-imine (3a–g) with 9-chloro-2,4-(un)substituted acridine (1a–c) and 9-isothiocyanato-2,4-(un)substituted acridine (2a–d), respectively. All these compounds were characterized by correct 1H NMR, FT-IR, MS and elemental analyses. These compounds were screened for anti-inflammatory, analgesic and kinase (CDK1, CDK5 and GSK3) inhibition activities. Some compounds exhibited good anti-inflammatory (25–32%) and potent analgesic (50–75%) activities, at 50 mg/kg p.o. A compound, 4o (R1 = H, R2 = OCH3, R3 = CH3, R4 = CH3, R5 = H) exhibited moderate CDK1 (IC50 = 8.5 μM) inhibition activity. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsiever | en_US |
dc.subject | Chemistry | en_US |
dc.subject | Synthesis | en_US |
dc.subject | Acridinyl-thiazolino derivatives | en_US |
dc.subject | Anti-inflammatory | en_US |
dc.subject | Analgesic | en_US |
dc.subject | CDK1 inhibitor | en_US |
dc.title | Synthesis of acridinyl-thiazolino derivatives and their evaluation for anti-inflammatory, analgesic and kinase inhibition activities | en_US |
dc.type | Article | en_US |
Appears in Collections: | Department of Chemistry |
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