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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Bajaj, Kiran | - |
| dc.date.accessioned | 2021-11-11T11:24:42Z | - |
| dc.date.available | 2021-11-11T11:24:42Z | - |
| dc.date.issued | 2003-11-01 | - |
| dc.identifier.uri | https://europepmc.org/article/med/14604692 | - |
| dc.identifier.uri | http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/3517 | - |
| dc.description.abstract | Diazotization of N-benzylidene anthranilic acids 1a-1n at pH 9 yielded N-[alpha-(phenylazo) benzylidene] anthranilic acids 2a-2n and at pH 3 yielded N-benzylidene-5-(phenylazo) anthranilic acids 3a-3n. When compounds 3a-3n were treated with thioglycolic/thiolactic acid in the presence of anhydrous ZnCl(2), 2-(4-oxo-2-phenylthiazolidin-3-yl)-5-(phenylazo) benzoic acids 4a-4n were afforded. The newly synthesized compounds were screened for their anti-inflammatory and analgesic activities and were compared with standard drugs, aspirin and phenylbutazone. Out of the compounds studied, the most active compound 4n showed more potent activity than the standard drugs at all doses tested. | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | PMC | en_US |
| dc.subject | Chemistry | en_US |
| dc.subject | Synthesis | en_US |
| dc.subject | Anti-inflammatory | en_US |
| dc.subject | Analgesic agents | en_US |
| dc.title | Synthesis of some newer derivatives of 2-amino benzoic acid as potent anti-inflammatory and analgesic agents. | en_US |
| dc.type | Article | en_US |
| Appears in Collections: | Department of Chemistry | |
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