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Please use this identifier to cite or link to this item: http://dspace.bits-pilani.ac.in:8080/jspui/handle/123456789/3521
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dc.contributor.authorBajaj, Kiran-
dc.date.accessioned2021-11-11T11:24:58Z-
dc.date.available2021-11-11T11:24:58Z-
dc.date.issued2003-
dc.identifier.urihttps://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0031-1297113-
dc.identifier.urihttp://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/3521-
dc.description.abstract2-Amino-5-(heteroarylmethylene)-1,3,4-oxadiazoles/thiadiazoles 7−10 were synthesized by cyclisation of 1-(heteroarylacetyl)semicarbazides/thiosemicarbazides 3−6. 5-(2’-Heteroarylmethylene-5’-aminomethylene-1’, 3’, 4’-oxadiazol-2’-yl/ thiadiazol-2’-yl)-2-oxo/thiobarbituric acids 11−18 were synthesized by condensation of compounds 7−10 at the 5th position of 2-oxo/thiobarbituric acids. The newly synthesized compounds showed anticonvulsant activity ranging from 50–90 % (seizures protection). Compound 18 (5-(2’-phenothiazinylmethylene-5’-aminomethylene-1’,3’,4’-thiadiazol-2’-yl)-2-thiobarbituric acid) showed maximum activity being more potent than the reference drug phenytoin sodium (CAS 630-93-3)en_US
dc.language.isoenen_US
dc.publisherThiemeen_US
dc.subjectChemistryen_US
dc.subjectSynthesisen_US
dc.subjectOxo/thiobarbituric acid derivativesen_US
dc.subjectAnticonvulsant acitvityen_US
dc.titleSynthesis of Newer Indolyl/ Phenothiazinyl Substituted 2-Oxo/ Thiobarbituric Acid Derivatives as Potent Anticonvulsant Agentsen_US
dc.typeArticleen_US
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