Browsing by Author "Gaikwad, Anil Bhanudas"

Advanced non-invasive diagnostic techniques for visualization and estimation of kidney fibrosis

Gaikwad, Anil Bhanudas (Elsevier, 2021-08)

Kidney fibrosis is marked by excessive extracellular matrix deposition during disease progression. Unfortunately, existing kidney function parameters do not predict the extent of kidney fibrosis. Moreover, the traditional ...

Ameliorative effect of AT2R and ACE2 activation on ischemic renal injury associated cardiac and hepatic dysfunction

Gaikwad, Anil Bhanudas (Elsevier, 2020-11)

This study explored the role of the depressor arm of renin-angiotensin system (RAS) on ischemic renal injury (IRI)-associated cardio-hepatic sequalae under non-diabetic (ND) and diabetes mellitus (DM) conditions. Firstly, ...

Angiotensin II type 2 receptor and angiotensin-converting enzyme 2 mediate ischemic renal injury in diabetic and non-diabetic rats

Gaikwad, Anil Bhanudas (Elsevier, 2019-10)

Depressor arm of the renin-angiotensin system (RAS) exerts reno-protective effects in chronic kidney diseases like diabetic nephropathy. However, same is still elusive under AKI and hyperglycaemia comorbidity. Hence, the ...

AT2 receptor agonist Compound 21: A silver lining for diabetic nephropathy

Gaikwad, Anil Bhanudas (Elsevier, 2017-11)

The currently available therapies for diabetic nephropathy, one of the leading causes of renal failure globally are based on inhibition of renin angiotensin system. However, recently, the focus has shifted towards activation ...

Beneficial Effects of Nuts From India in Cardiovascular Disorders

Gaikwad, Anil Bhanudas (Elsevier, 2020)

Drugs from nature are in incredible demand in various countries for essential human health services because of their wide therapeutic effects and lesser expenses. Medicinal plants are important source of compounds with ...

Biomarkers of Multiple Sclerosis and Their Modulation by Natural Products

Gaikwad, Anil Bhanudas (Elsevier, 2017)

Multiple sclerosis (MS) is one of the leading causes of neurological disabilities and can be explained as a chronic, inflammatory, and autoimmune disease related to the central nervous system. Biomarkers play an important ...

Capsicum: A Natural Pain Modulator

Gaikwad, Anil Bhanudas (Elsevier, 2017)

Pain is not only an obnoxious sensation, but also a complex sensory process essential for survival experienced due to activation nociceptors. Many herbal medicines have been used in the management of pain in various ...

Change in histone H3 phosphorylation, MAP kinase p38, SIR 2 and p53 expression by resveratrol in preventing streptozotocin induced type I diabetic nephropathy

Gaikwad, Anil Bhanudas (Taylor & Francis, 2009-07)

Resveratrol has been reported to have a wide variety of biological effects. However, little is known regarding its role on phosphorylation of histone H3, MAP kinase p38, SIR2 and p53 in type I diabetic nephropathy (DN). ...

Change in post-translational modifications of histone H3, heat-shock protein-27 and MAP kinase p38 expression by curcumin in streptozotocin-induced type I diabetic nephropathy

Gaikwad, Anil Bhanudas (Wiley, 2009-01)

Curcumin has been used to treat cancer, diabetes and other pathologies. However, little is known regarding its role in altering post-translational modifications of histone H3. A recent report suggests that acute hyperglycaemia ...

Combination of aspirin with telmisartan suppresses the augmented TGFβ/smad signaling during the development of streptozotocin-induced type I diabetic nephropathy

Gaikwad, Anil Bhanudas (Elsevier, 2010-04)

Diabetic nephropathy (DN) is the most common indication for the development of end stage renal diseases. Inflammation is increasingly seen as the core process in the development of diabetes. Inflammatory markers e.g. NFκB ...

Compound 21 and Telmisartan combination mitigates type 2 diabetic nephropathy through amelioration of caspase mediated apoptosis

Gaikwad, Anil Bhanudas (Elsevier, 2017-06)

The current study aimed to understand the role of novel, highly selective, orally active, non-peptide Angiotensin II type 2 receptor (AT2R) agonist, Compound 21 and its potential additive effect with Telmisartan on apoptosis ...

Concomitant inhibition of TLR-4 and SGLT2 by phloretin and empagliflozin prevents diabetes-associated ischemic acute kidney injury

Gaikwad, Anil Bhanudas (RSC, 2023-04)

Toll-like receptor-4 (TLR4) and sodium-glucose co-transporter 2 (SGLT2) signaling is involved in the pathogenesis of diabetes-associated kidney diseases. The purpose of this study was to explore the role and effect of ...

Concurrent neprilysin inhibition and renin-angiotensin system modulations prevented diabetic nephropathy

Gaikwad, Anil Bhanudas (Elsevier, 2019-03)

Renin-angiotensin system (RAS) and natriuretic peptides system (NPS) perturbations govern the development of diabetic nephropathy (DN). Hence, in search of a novel therapy against DN, present study targeted both, NPS and ...

Crosstalk between kidney and liver in non-alcoholic fatty liver disease: mechanisms and therapeutic approaches

Gaikwad, Anil Bhanudas (Taylor & Francis, 2020-03)

Liver and kidney are vital organs that maintain homeostasis and injury to either of them triggers pathogenic pathways affecting the other. For example, non-alcoholic fatty liver disease (NAFLD) promotes the progression of ...

Curcumin as an Adjuvant to Breast Cancer Treatment

Gaikwad, Anil Bhanudas (Bentham Science, 2015-06)

Cancer is the second largest leading cause of death worldwide and breast cancer is the most prevailing cause of mortality among all cases of malignant neoplastic disease in adult females. The incidence rate of breast ...

Curcumin: The epigenetic therapy

Gaikwad, Anil Bhanudas (Elsevier, 2016)

The process of gene expression is tightly regulated by a series of interconnected epigenetic alterations including DNA methylation, covalent modifications of histones, or altered microRNA. The food components which are ...

Cyproheptadine, a SET7/9 inhibitor, reduces hyperglycaemia-induced ER stress alleviating inflammation and fibrosis in renal tubular epithelial cells

Gaikwad, Anil Bhanudas (Taylor & Francis, 2022-08)

Persistent hyperglycaemia increases SET7/9 expression and endoplasmic reticulum (ER) stress which causes inflammation, apoptosis, and fibrosis in renal tubular epithelial cells leading to diabetic kidney disease (DKD)

Diabetes and Cardiorenal Complications: A Clinical Review of Existing Therapies and Novel Combinations, Focusing on SGLT2 Inhibitors

Gaikwad, Anil Bhanudas (Bentham Science, 2023-11)

Type 2 diabetes mellitus (T2DM) is a set of metabolic disorders specified by hyperglycemia as a result of abnormalities in insulin secretion or sensitivity. Chronic kidney disease (CKD) and cardiovascular disease (CVD) are ...

Diabetes, diabetic complications, and flavonoids

Gaikwad, Anil Bhanudas (Elsevier, 2016)

Diabetes mellitus is among the most prevalent diseases with which a large population of world is suffering from. Incidence of diabetes is on rise all over the world. Hence management of diabetes and related complications ...

Diabetic nephropathy: The regulatory interplay between epigenetics and microRNAs

Gaikwad, Anil Bhanudas; Gaikwad, Anil Bhanudas (Elsevier, 2019-03)

Diabetic nephropathy (DN) is still one of the leading causes of end-stage renal disease despite the emergence of different therapies to counter the metabolic, hemodynamic and fibrotic pathways, implicating a prominent role ...

Browsing by Author "Gaikwad, Anil Bhanudas"

Browsing by Author "Gaikwad, Anil Bhanudas"

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