Browsing by Author "Pandey, Murali Monohar"

Cold atmospheric plasma therapy in wound healing

Pandey, Murali Monohar (Elsevier, 2022-01)

Cold atmospheric plasma therapy is a new and latest approach whose arrival has astonished experts all around the world from the area of biological and pharmaceutical sciences. Owing to its simple and non-invasive nature, ...

Controlled release effervescent buccal discs of buspirone hydrochloride: in vitro and in vivo evaluation studies

Pandey, Murali Monohar (Taylor & Francis, 2014-06)

In the present study controlled release effervescent buccal discs of buspirone hydrochloride (BS) were designed using HPMC as rate controlling and bioadhesive polymer by direct compression method. Sodium bicarbonate and ...

Current Treatment Strategies Against Multidrug-Resistant Bacteria: A Review

Pandey, Murali Monohar (Springer, 2022-11)

There are several bacteria called superbugs that are resistant to multiple antibiotics which can be life threatening specially for critically ill and hospitalized patients. This article provides up-to-date treatment ...

Design and evaluation of mucoadhesive buccal delivery systems of felodipine

Pandey, Murali Monohar (BITS Pilani, 2015)

The objective of the present work was to design and evaluate mucoadhesive newlinebuccal drug delivery systems of felodipine (FDP). FDP, a 1,4-dihydropyridine newlinederivative, is a vasoselective calcium antagonist widely ...

Design of Experiment (DoE)-Approach Based RP-HPLC Analytical Method Development and Validation for Estimation of Efavirenz in Bulk and Formulations

Pandey, Murali Monohar (OUP, 2021-03)

Present study reports design of experiment (DoE) based development and validation of a simple, rapid and sensitive reversed-phase high-performance liquid chromatography (RP-HPLC) method for estimation of efavirenz (EFZ), ...

Determination of pKa of felodipine using UV–Visible spectroscopy

Pandey, Murali Monohar (Elsevier, 2013-11)

In the present study, for the first time, experimental pKa value of felodipine is reported. Dissociation constant, pKa, is one of the very important physicochemical properties of drugs. It is of paramount significance from ...

Development and Validation of a Simple High-Performance Liquid Chromatography Method for Estimation of Felodipine in Rabbit Plasma: Application to Pharmacokinetic Study

Pandey, Murali Monohar (Bentham Science, 2017)

A new, simple, specific and sensitive reverse-phase liquid chromatographic method was developed and validated for the estimation of felodipine (FDP) in rabbit plasma using fluorescence detector. Materials and Methods: ...

Dissolution enhancement of felodipine by amorphous nanodispersions using an amphiphilic polymer: insight into the role of drug–polymer interactions on drug dissolution

Pandey, Murali Monohar (Taylor & Francis, 2015-03)

Felodipine, a poorly soluble drug, is widely used in the treatment of angina pectoris and hypertension.

DoE-based validation of a HPLC–UV method for quantification of rotigotine nanocrystals: Application to in vitro dissolution and ex vivo nasal permeation studies

Pandey, Murali Monohar (Wiley, 2021-11)

The current work is focused on optimization, development, and validation of a sensitive and specific reversed-phase high-performance liquid chromatography (RP-HPLC) method for the estimation of rotigotine (RTG) in bulk and ...

Effect of HPMC and mannitol on drug release and bioadhesion behavior of buccal discs of buspirone hydrochloride: In-vitro and in-vivo pharmacokinetic studies

Pandey, Murali Monohar (Merck KGaA, 2015)

Delivery of orally compromised therapeutic drug molecules to the systemic circulation via buccal route has gained a significant interest in recent past. Bioadhesive polymers play a major role in designing such buccal dosage ...

Emerging trends of nanotechnology in advanced cosmetics

Pandey, Murali Monohar; Singhvi, Gautam (Elsevier, 2022-06)

The cosmetic industry is dynamic and ever-evolving. Especially with the introduction and incorporation of nanotechnology-based approaches into cosmetics for evincing novel formulations that confers aesthetic as well as ...

Engineering of structural and functional properties of nanotherapeutics and nanodiagnostics for intranasal brain targeting in Alzheimer's

Pandey, Murali Monohar (Elsevier, 2022-03)

Alzheimer's disease (AD) is the fifth leading cause of death on the planet. It hallmarks the presence of amyloid plaques and neurofibrillary tangles in geriatric patients. The condition witnesses early stages of mild ...

Interaction of calcium sulfate with xanthan gum: Effect on in vitro bioadhesion and drug release behavior from xanthan gum based buccal discs of buspirone

Pandey, Murali Monohar (Elsevier, 2013-11)

Bioadhesive polymers in buccal drug delivery systems play an important role in delivery of therapeutic drug molecules for local and systemic action. Xanthan gum, a GRAS listed natural polymer was used to design buccal discs ...

Intranasal nanotherapeutics for brain targeting and clinical studies in Parkinson's disease

Pandey, Murali Monohar (Elsevier, 2023-06)

Parkinson's disease (PD) is the second leading neurodegenerative disease globally, impacting the quality of life of millions of people. It is estimated that the treatment cost of PD in the USA can rise to 79 billion dollars ...

Microneedles: A smart approach and increasing potential for transdermal drug delivery system

Pandey, Murali Monohar; Singhvi, Gautam (Elsevier, 2019-01)

The most widely used methods for transdermal administration of the drugs are hypodermic needles, topical creams, and transdermal patches. The effect of most of the therapeutic agents is limited due to the stratum corneum ...

Nanomedicine advances in cancer therapy

Singhvi, Gautam; Pandey, Murali Monohar (Elsevier, 2020)

Cancer has been one of the leading causes of death worldwide. In 2018, 17 million new cases of cancer have been reported across the world, which resulted in 9.6 million deaths. Continued efforts have been made to achieve ...

Nose-to-brain delivery of rotigotine redispersible nanosuspension: In vitro and in vivo characterization

Pandey, Murali Monohar (Elsevier, 2023-01)

Rotigotine (RTG) is an anti-Parkinson's drug approved by the USFDA to treat motor and non-motor symptoms of both early and advanced stages of the disease. However, issues like poor aqueous solubility, low oral bioavailability ...

(Re)Formulating rotigotine: a potential molecule with unmet needs

Pandey, Murali Monohar; Chitkara, Deepak (Future Science Group, 2023-01)

Rotigotine (RTG), a non-ergoline D3/D2/D1 dopamine receptor agonist, is indicated for Parkinson’s disease (PD) and restless leg syndrome (RLS)[1]. It also has an affinity toward serotonin (5-HT1A, 5-HT2B, and 5-HT7) and ...

Rivastigmine-DHA ion-pair complex improved loading in hybrid nanoparticles for better amyloid inhibition and nose-to-brain targeting in Alzheimer’s

Pandey, Murali Monohar (Elsevier, 2023-09)

Rivastigmine hydrogen tartrate (RIV-HT) is given orally for Alzheimer's disease. However, oral therapy shows low brain bioavailability, short half-life and gastrointestinal-mediated adverse effects. RIV-HT intranasal ...

Self-Assembled Lecithin-Chitosan Nanoparticles Improved Rotigotine Nose-to-Brain Delivery and Brain Targeting Efficiency

Chitkara, Deepak; Pandey, Murali Monohar (MDPI, 2023-03)

Rotigotine (RTG) is a non-ergoline dopamine agonist and an approved drug for treating Parkinson’s disease. However, its clinical use is limited due to various problems, viz. poor oral bioavailability (<1%), low aqueous ...

Browsing by Author "Pandey, Murali Monohar"

Browsing by Author "Pandey, Murali Monohar"

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