Browsing by Subject "BACE-1 (β-secretase)"

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Design, synthesis and in vitro evaluation studies of sulfonyl-amino-acetamides as small molecule BACE-1 inhibitors

Jadhav, Hemant R. (Elsevier, 2016-06)

The identification of a series of sulfonyl-amino-acetamides as BACE-1 (β-secretase) inhibitors for the treatment of Alzheimer’s disease is reported. The derivatives were designed based on the docking simulation study, ...
Rational design, synthesis and in vitro evaluation of allylidene hydrazinecarboximidamide derivatives as BACE-1 inhibitors

Mahesh, R. (Elsevier, 2016-01)

BACE-1 (β-secretase) is considered to be one of the promising targets for treatment of Alzheimer’s disease as it catalyzes the rate limiting step of Aβ-42 production. Herein, we report a novel class of allylidene ...

Now showing items 1-2 of 2

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