| dc.contributor.author |
Mahesh, R. |
|
| dc.date.accessioned |
2023-11-20T07:05:03Z |
|
| dc.date.available |
2023-11-20T07:05:03Z |
|
| dc.date.issued |
2004 |
|
| dc.identifier.uri |
https://www.jstage.jst.go.jp/article/bpb/27/9/27_9_1403/_article/-char/ja/ |
|
| dc.identifier.uri |
http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/13179 |
|
| dc.description.abstract |
A series of 3-chloroquinoxaline-2-carboxamides were designed and prepared by the condensation of 3-chloro-2-quinoxaloylchloride with appropriate Mannich bases of the p-aminophenol in the microwave environment. The synthesized compounds were evaluated for serotonin3 (5-HT3) receptor antagonistic activities in longitudinal muscle-myenteric plexus (LMMP) preparation from guinea pig ileum against the 5-HT3 agonist, 2-methyl-5-HT. Compound 3g exhibited comparable 5-HT3 antagonistic activity (pA2 6.4) to that of standard antagonist Ondansetron (pA2 6.9), while the other compounds exhibited mild to moderate 5-HT3 antagonistic activities. |
en_US |
| dc.language.iso |
en |
en_US |
| dc.publisher |
The Pharmaceutical Society of Japan |
en_US |
| dc.subject |
Pharmacy |
en_US |
| dc.subject |
Pharmacophore |
en_US |
| dc.subject |
5-HT3 receptor antagonist |
en_US |
| dc.title |
Pharmacophore Based Synthesis of 3-Chloroquinoxaline-2-carboxamides as Serotonin3 (5-HT3) Receptor Antagonist |
en_US |
| dc.type |
Article |
en_US |