dc.contributor.author |
Mahesh, R. |
|
dc.date.accessioned |
2023-11-20T10:53:16Z |
|
dc.date.available |
2023-11-20T10:53:16Z |
|
dc.date.issued |
2010-05 |
|
dc.identifier.uri |
https://nopr.niscpr.res.in/bitstream/123456789/8483/1/IJEB%2048%285%29%20466-473.pdf |
|
dc.identifier.uri |
http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/13191 |
|
dc.description.abstract |
Disruption of normal neuronal networks and neurotransmitters like serotonin and norepinephrine levels in post traumatic brain injury (TBI) are observed to be the primary causative agent for depression/anxiety. This communication reports the efficacy of various classes' anti-depressants in the treatment of depression/anxiety following TBI in rats. Chronic treatment with anti-depressants (escitalopram and venlafaxine) leads to improvement in the depressive/anxiogenic-like behaviour in the TBI rat and corroborates the notion of the involvement of serotonin and norepinephrine in the behavioural consequences of post-TBI. Chronic treatments with escitalopram and venlafaxine significantly reversed the effect of TBI as compared to vehicle-treated TBI group. The results showed a quantitative battery of neuro-behavioural functional assessments that correlates with neuronal damage following traumatic brain injury |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
NISCAIR |
en_US |
dc.subject |
Pharmacy |
en_US |
dc.subject |
Traumatic brain injury (TBI) |
en_US |
dc.subject |
Anti-depressants |
en_US |
dc.title |
Effect of anti-depressants on neuro-behavioural consequences following impact accelerated traumatic brain injury in rats |
en_US |
dc.type |
Article |
en_US |