| dc.contributor.author |
Mahesh, R. |
|
| dc.date.accessioned |
2023-11-21T05:03:41Z |
|
| dc.date.available |
2023-11-21T05:03:41Z |
|
| dc.date.issued |
2012-09 |
|
| dc.identifier.uri |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480784/ |
|
| dc.identifier.uri |
http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/13200 |
|
| dc.description.abstract |
The present study was designed to investigate the antidepressant potential of (4-phenylpiperazin-1-yl) (quinoxalin-3-yl) methanone (4a), a novel 5-HT3 receptor antagonist, with an optimal log P (2.84) and pA2 value (7.3) greater than ondansetron (6.9) using rodent behavioural models of depression. |
en_US |
| dc.language.iso |
en |
en_US |
| dc.publisher |
Wolters Kluwer |
en_US |
| dc.subject |
Pharmacy |
en_US |
| dc.subject |
(4-phenylpiperazin-1-yl) (quinoxalin-2-yl) methanone |
en_US |
| dc.subject |
4a |
en_US |
| dc.subject |
5-HT3 receptor antagonist |
en_US |
| dc.subject |
Depression |
en_US |
| dc.subject |
Forced swim test (FST) |
en_US |
| dc.subject |
Olfactory bulbectomy (OBX) |
en_US |
| dc.title |
Antidepressant-like activity of (4-phenylpiperazin-1-yl) (quinoxalin-2-yl) methanone (4a), a novel 5-HT3 receptor antagonist: An investigation in behaviour-based rodent models of depression |
en_US |
| dc.type |
Article |
en_US |