| dc.contributor.author |
Mahesh, R. |
|
| dc.date.accessioned |
2023-11-21T05:06:36Z |
|
| dc.date.available |
2023-11-21T05:06:36Z |
|
| dc.date.issued |
2011-01 |
|
| dc.identifier.uri |
https://www.tandfonline.com/doi/full/10.3109/14756366.2010.543419 |
|
| dc.identifier.uri |
http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/13201 |
|
| dc.description.abstract |
A series of quinoxalin-2-carboxamides were designed as per the pharmacophoric requirements of 5-HT3 receptor antagonists and synthesized by condensing the carboxylic group of quinoxalin-2-carboxylic acid with various amines in the presence of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and 1-hydroxybenzotriazole. The structures of the synthesized compounds were confirmed by physical and spectroscopic data. The carboxamides were evaluated for their 5-HT3 receptor antagonisms in longitudinal muscle-myenteric plexus preparation from guinea pig ileum against 5-HT3 agonist, 2-methy-5-HT. All the synthesized compounds showed 5-HT3 receptor antagonism, (4-benzylpiperazin-1-yl)(quinoxalin-2-yl)methanone was the most potent compound among this series. |
en_US |
| dc.language.iso |
en |
en_US |
| dc.publisher |
Taylor & Francis |
en_US |
| dc.subject |
Pharmacy |
en_US |
| dc.subject |
Quinoxalin-2-carboxamides |
en_US |
| dc.subject |
Serotonin system |
en_US |
| dc.subject |
5-HT3 receptor antagonists |
en_US |
| dc.subject |
Quinoxaline |
en_US |
| dc.title |
Quinoxalin-2-carboxamides: synthesis and pharmacological evaluation as serotonin type-3 (5-HT3) receptor antagonists |
en_US |
| dc.type |
Article |
en_US |