DSpace Repository

Anti-depressant like Effect of Pimozide in Acute and Chronic Animal Models of Depression

Show simple item record

dc.contributor.author Mahesh, R.
dc.date.accessioned 2023-11-22T09:35:43Z
dc.date.available 2023-11-22T09:35:43Z
dc.date.issued 2015-02
dc.identifier.uri https://www.ijper.org/article/306
dc.identifier.uri http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/13222
dc.description.abstract The hope of developing better antidepressants has stimulated research on 5-HT receptor, capable of producing diverse antidepressant-like 7 behavioral effects. In the current study, the pimozide, a novel 5-HT receptor antagonist, was screened for its antidepressant potential in 7 rodent's behavioral test battery. Psycho-pharmacological investigations involved acute and chronic treatment (14 days) of pimozide in forced swim test (FST), tail suspension test (TST) in mice and olfactory bulbectomy in rats, respectively. Dose response study in mice FST and TST revealed the initial antidepressant-like effect of pimozide (0.5-4mg/kg i.p.). Interaction studies revealed that pimozide (1and 2mg/kg) significantly enhanced the antidepressant action of citalopram and bupropion in mice FST and TST respectively. Reversal of reserpine induced hypothermia (rats) was observed at same dose level. Further, the behavior anomalies exhibited by olfactory bulbectomised rats (OBX) were attenuated by chronic pimozide treatment as observed in open field and hyper-emotionality tests. In conclusion, this behavioural study depicts the antidepressant-like effect of pimozide in rodent's behavioural model. en_US
dc.language.iso en en_US
dc.publisher IJPER en_US
dc.subject Pharmacy en_US
dc.subject Anti-depressant-like effect en_US
dc.subject 5-HT3 antagonist en_US
dc.subject Pimozide en_US
dc.subject Forced swim test (FST) en_US
dc.subject Olfactory bulbectomy (OBX) en_US
dc.title Anti-depressant like Effect of Pimozide in Acute and Chronic Animal Models of Depression en_US
dc.type Article en_US


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account