dc.contributor.author |
Mahesh, R. |
|
dc.date.accessioned |
2023-11-23T06:35:42Z |
|
dc.date.available |
2023-11-23T06:35:42Z |
|
dc.date.issued |
2014-04 |
|
dc.identifier.uri |
https://www.sysrevpharm.org/abstract/role-of-serotonin-type1ab-hydroxytryptamine-receptors-in-depression-revisited-64927.html |
|
dc.identifier.uri |
http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/13233 |
|
dc.description.abstract |
Depression is among the common psychiatric disorders, therefore the common pathways
and pathogenesis associated with depression is required to be studied. In few years, role of
5-hydroxytryptamine-1A/B (5-HT1A/B) receptors in depressive disorders have been revealed. Both
preclinical and clinical studies reported that the potential agonist and antagonist at 5-HT1A/B
receptors have significant modulatory effects in depression. However, the collective details
regarding the involvement of 5-HT1A/B receptors and the molecular pathways associated in
depression is lacking. Thus, the present review evidence the link between 5-HT1A/B receptors in
the brain and depression, the possible pathways involved and their alterations in depression.
Further, it reviews the preclinical evidences of 5-HT1A/B receptor modulators as antidepressant
agents and their effectiveness. The current review also details the clinical relevance of 5-HT1A/B
receptors etiopathogenesis of major depression in humans. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Systematic Reviews in Pharmacy |
en_US |
dc.subject |
Pharmacy |
en_US |
dc.subject |
5-hydroxytryptophan |
en_US |
dc.subject |
Antidepressant |
en_US |
dc.subject |
Depression |
en_US |
dc.subject |
Molecular signaling |
en_US |
dc.title |
Role of Serotonin Type-1A/B (Hydroxytryptamine) Receptors in Depression Revisited |
en_US |
dc.type |
Article |
en_US |