| dc.contributor.author |
Taliyan, Rajeev |
|
| dc.date.accessioned |
2023-12-14T06:54:46Z |
|
| dc.date.available |
2023-12-14T06:54:46Z |
|
| dc.date.issued |
2017-07 |
|
| dc.identifier.uri |
https://alz-journals.onlinelibrary.wiley.com/doi/full/10.1016/j.jalz.2017.06.780 |
|
| dc.identifier.uri |
http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/13421 |
|
| dc.description.abstract |
Alzheimer's disease (AD) is characterized by the progressive deposition of fibrillar amyloid-β (Aβ) in the form of extracellular plaques and hyperphosphorylated tau as intraneuronal neuro fibrillary tangles (NFTs). Studies have reported that increased Glycogen synthase kinase-3β (GSK-3β) activity has been associated with hyper phosphorylation of tau. However, the molecular mechanisms of association still remain elusive. Thus, the present study was designed to explore the potential of GSK-3β inhibitor, AR-A014418 in high fat diet (HFD) induced cognitive impairment and AD like pathology. |
en_US |
| dc.language.iso |
en |
en_US |
| dc.publisher |
Wiley |
en_US |
| dc.subject |
Pharmacy |
en_US |
| dc.subject |
Alzheimer's disease (AD) |
en_US |
| dc.subject |
Glycogen synthase kinase-3β |
en_US |
| dc.subject |
High Fat Diet (HFD) |
en_US |
| dc.title |
[P2–130]: AR-A014418, A GSK-3β INHIBITOR, ATTENUATES ALZHEIMER'S- LIKE PATHOLOGY IN HIGH FAT DIET-INDUCED COGNITIVE DEFICIT IN MICE |
en_US |
| dc.type |
Article |
en_US |