Abstract:
Diabetes Mellitus is a metabolic disorder characterized by insulin resistance with several metabolic abnormalities which trigger neuronal complications, neurodegeneration, and cognitive impairments. Repaglinide (REP) is an insulinotropic, neuroprotective agent with short-action and poor absorption characteristics. Hence, the present study was aimed to investigate the efficacy of REP-loaded lipid polymer-hybrid nanoparticles (REP-LPHNPs) in High Fat Diet low dose of Streptozotocin (HFD-STZ) induced cognitive deficits wistar rats model.