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Change in histone H3 phosphorylation, MAP kinase p38, SIR 2 and p53 expression by resveratrol in preventing streptozotocin induced type I diabetic nephropathy

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dc.contributor.author Gaikwad, Anil Bhanudas
dc.date.accessioned 2023-12-19T04:21:34Z
dc.date.available 2023-12-19T04:21:34Z
dc.date.issued 2009-07
dc.identifier.uri https://www.tandfonline.com/doi/abs/10.1080/10715760801998646
dc.identifier.uri http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/13442
dc.description.abstract Resveratrol has been reported to have a wide variety of biological effects. However, little is known regarding its role on phosphorylation of histone H3, MAP kinase p38, SIR2 and p53 in type I diabetic nephropathy (DN). Hence, the present study was undertaken to examine changes in the above said parameters by resveratrol treatment. Male Sprague-Dawley rats were rendered diabetic using a single dose of streptozotocin (55 mg/kg, i.p.). DN was assessed by measurements of blood urea nitrogen and creatinine levels. Phosphorylation of histone H3, SIR2, p53 and MAP kinase p38 expression were examined by western blotting. This study reports that treatment of resveratrol prevents the decrease in the expression of SIR2 in diabetic kidney. It also prevents increase in p38, p53 expression and dephosphorylation of histone H3 in diabetic kidney. This is the first report which suggests that protection against development of diabetic nephropathy by resveratrol treatment involves change in phosphorylation of histone H3, expression of Sir-2, p53 and p38 in diabetic kidney en_US
dc.language.iso en en_US
dc.publisher Taylor & Francis en_US
dc.subject Pharmacy en_US
dc.subject Diabetic nephropathy en_US
dc.subject SIR2 en_US
dc.subject Oxidative stress en_US
dc.subject p38 en_US
dc.subject H3 phosphorylation en_US
dc.subject p53 en_US
dc.title Change in histone H3 phosphorylation, MAP kinase p38, SIR 2 and p53 expression by resveratrol in preventing streptozotocin induced type I diabetic nephropathy en_US
dc.type Article en_US


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