| dc.contributor.author |
Gaikwad, Anil Bhanudas |
|
| dc.date.accessioned |
2023-12-19T04:23:58Z |
|
| dc.date.available |
2023-12-19T04:23:58Z |
|
| dc.date.issued |
2007-05 |
|
| dc.identifier.uri |
https://www.sciencedirect.com/science/article/pii/S0014579307004231 |
|
| dc.identifier.uri |
http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/13443 |
|
| dc.description.abstract |
Cisplatin is a widely used antineoplastic drug. Major drawback of cisplatin therapy is its nephrotoxicity. The objective of this study was to check the effect of tannic acid on cisplatin induced nephrotoxicity. Post-treatment of tannic acid prevents cisplatin (5 mg/kg) induced nephrotoxicity and decreases poly(ADP-ribose) polymerase cleavage, phosphorylation of p38 and hypoacetylation of histone H4. In contrast, co-treatment of tannic acid potentiates the nephrotoxicity. Comparative nephrotoxicity studies show that co-treatment of tannic acid with reduced dose of cisplatin (1.5 mg/kg) developed almost similar nephrotoxicity. MALDI protein profiling of plasma samples provides indirect evidence that tannic acid co-treatment increases bioavailability of cisplatin. |
en_US |
| dc.language.iso |
en |
en_US |
| dc.publisher |
Elsevier |
en_US |
| dc.subject |
Pharmacy |
en_US |
| dc.subject |
Cisplatin |
en_US |
| dc.subject |
Nephrotoxicity |
en_US |
| dc.subject |
Poly(ADP-ribose) polymerase |
en_US |
| dc.subject |
Histone H4 |
en_US |
| dc.subject |
P-p38 and Tannic acid |
en_US |
| dc.title |
Differential effects of tannic acid on cisplatin induced nephrotoxicity in rats |
en_US |
| dc.type |
Article |
en_US |