| dc.contributor.author | Chitkara, Deepak | |
| dc.date.accessioned | 2024-01-03T09:25:30Z | |
| dc.date.available | 2024-01-03T09:25:30Z | |
| dc.date.issued | 2013-07 | |
| dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0304383512005964 | |
| dc.identifier.uri | http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/13641 | |
| dc.description.abstract | Pancreatic cancers relapse due to small but distinct population of cancer stem cells (CSCs) which are in turn regulated by miRNAs. The present study identifies a series of miRNAs which were either upregulated (e.g. miR-146) or downregulated (e.g. miRNA-205, miRNA-7) in gemcitabine resistant MIA PaCa-2 cancer cells and clinical metastatic pancreatic cancer tissues. Gemcitabine resistant MIA PaCa-2 cells possessed distinct ALDH-positive CSC fraction expressing stem cell markers OCT3/4 and CD44 and chemoresistance marker class III β-tubulin (TUBB3) which decreases on transfection with miR-205 resulting in the restoration of chemosensitivity to gemcitabine. | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | Elsevier | en_US |
| dc.subject | Pharmacy | en_US |
| dc.subject | Pancreatic cancer | en_US |
| dc.subject | Chemoresistance | en_US |
| dc.subject | miRNAs | en_US |
| dc.subject | Gemcitabine | en_US |
| dc.subject | Cancer stem cells | en_US |
| dc.title | miRNA profiling in pancreatic cancer and restoration of chemosensitivity | en_US |
| dc.type | Article | en_US |
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