| dc.contributor.author |
Sundriyal, Sandeep |
|
| dc.date.accessioned |
2024-01-17T04:44:28Z |
|
| dc.date.available |
2024-01-17T04:44:28Z |
|
| dc.date.issued |
2022-10 |
|
| dc.identifier.uri |
https://www.sciencedirect.com/science/article/pii/S0960894X12010013 |
|
| dc.identifier.uri |
http://dspace.bits-pilani.ac.in:8080/jspui/xmlui/handle/123456789/13852 |
|
| dc.description.abstract |
Bacterial resistance to β-lactam antibiotics caused by class B metallo-β-lactamases (MBL), especially for certain hospital-acquired, Gram-negative pathogens, poses a significant threat to public health. We report several 2-substituted 4,5-dihydrothiazole-4-carboxylic acids to be novel MBL inhibitors. Structure activity relationship (SAR) and molecular modeling studies were performed and implications for further inhibitor design are discussed. |
en_US |
| dc.language.iso |
en |
en_US |
| dc.publisher |
Elsevier |
en_US |
| dc.subject |
Pharmacy |
en_US |
| dc.subject |
Metallo-β-lactamase |
en_US |
| dc.subject |
Inhibitor |
en_US |
| dc.subject |
Rational design |
en_US |
| dc.subject |
Molecular modeling |
en_US |
| dc.title |
2-Substituted 4,5-dihydrothiazole-4-carboxylic acids are novel inhibitors of metallo-β-lactamases |
en_US |
| dc.type |
Article |
en_US |