| dc.contributor.author |
Sundriyal, Sandeep |
|
| dc.date.accessioned |
2024-01-17T04:55:07Z |
|
| dc.date.available |
2024-01-17T04:55:07Z |
|
| dc.date.issued |
2009-12 |
|
| dc.identifier.uri |
https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/cmdc.200900330 |
|
| dc.identifier.uri |
http://dspace.bits-pilani.ac.in:8080/jspui/xmlui/handle/123456789/13853 |
|
| dc.description.abstract |
The lead optimization of an antimicrobial hexapeptide Orn-D-Trp-D-Phe-Ile-D-Phe-His(1-Bzl)-NH2 depending on the hydrophobic or positive-charge character of amino acids at various positions along its sequence was performed, followed by biological evaluation and mechanistic studies. This led to the identification of a new class of antimicrobial hexapeptides that interact preferentially with the negatively charged phospholipids of a model bacterial membrane. |
en_US |
| dc.language.iso |
en |
en_US |
| dc.publisher |
Wiley |
en_US |
| dc.subject |
Pharmacy |
en_US |
| dc.subject |
Cytotoxicity |
en_US |
| dc.subject |
Antimicrobial Activities |
en_US |
| dc.subject |
Synthesis |
en_US |
| dc.subject |
Antimicrobial Hexapeptides |
en_US |
| dc.title |
New Antimicrobial Hexapeptides: Synthesis, Antimicrobial Activities, Cytotoxicity, and Mechanistic Studies |
en_US |
| dc.type |
Article |
en_US |