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Ball-Milling-Enabled Zn(OTf)2-Catalyzed Friedel–Crafts Hydroxyalkylation of Imidazo[1,2-a]pyridines and Indoles

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dc.contributor.author Kumar, Anil
dc.date.accessioned 2024-09-10T09:23:25Z
dc.date.available 2024-09-10T09:23:25Z
dc.date.issued 2023-02
dc.identifier.uri https://pubs.acs.org/doi/10.1021/acs.joc.2c02719
dc.identifier.uri http://dspace.bits-pilani.ac.in:8080/jspui/xmlui/handle/123456789/15508
dc.description.abstract A facile and efficient synthetic method for the construction of C3-hydroxyalkylated imidazo[1,2-a]pyridines and indoles by a Zn(OTf)2-catalyzed Friedel–Crafts hydroxyalkylation of imidazo[1,2-a]pyridines and indoles with carbonyl compounds under mechanochemical conditions is reported. Good product selectivity, shorter reaction time, ambient reaction temperature, tolerance of a wide range of functional groups, broad substrate scope, moderate to good yield of products, and scalability are the salient features of the developed methodology. en_US
dc.language.iso en en_US
dc.publisher ACS en_US
dc.subject Chemistry en_US
dc.subject Chemical Reactions en_US
dc.subject Ethyl groups en_US
dc.subject Indoles en_US
dc.subject Pyridines en_US
dc.subject Silica Nanoparticles (SiNP) en_US
dc.title Ball-Milling-Enabled Zn(OTf)2-Catalyzed Friedel–Crafts Hydroxyalkylation of Imidazo[1,2-a]pyridines and Indoles en_US
dc.type Article en_US


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