| dc.contributor.author |
Sakhuja, Rajeev |
|
| dc.date.accessioned |
2024-09-13T08:54:22Z |
|
| dc.date.available |
2024-09-13T08:54:22Z |
|
| dc.date.issued |
2022-09 |
|
| dc.identifier.uri |
https://pubs.acs.org/doi/10.1021/acs.orglett.2c02820 |
|
| dc.identifier.uri |
http://dspace.bits-pilani.ac.in:8080/jspui/xmlui/handle/123456789/15568 |
|
| dc.description.abstract |
A Rh(III)-catalyzed [5+2] annulation of vinyl tyrosines with symmetrical and unsymmetrical internal alkynes was achieved, furnishing a series of oxepine-mounted tyrosine-based unnatural amino acids. In addition, the chemical applicability of the developed strategy was exemplified by stapling amino acid/peptide-appended alkynes with vinyl tyrosines and late stage functionalization of tyrosine-containing dipeptides and tripeptide with internal alkynes. |
en_US |
| dc.language.iso |
en |
en_US |
| dc.publisher |
ACS |
en_US |
| dc.subject |
Chemistry |
en_US |
| dc.subject |
Annulations |
en_US |
| dc.subject |
Aromatic compounds |
en_US |
| dc.subject |
Hydrocarbons |
en_US |
| dc.subject |
Peptides and proteins |
en_US |
| dc.title |
Rhodium-Catalyzed Annulation of Vinylated Tyrosines with Internal Alkynes to Access Oxepine-Mounted Unnatural Tyrosines and Its Peptide Late Stage Functionalization |
en_US |
| dc.type |
Article |
en_US |