Nitric oxide (NO), a versatile bio-active molecule modulates cellular functions through diverse mechanisms including S-nitrosylation of proteins. Herein, we report S-nitrosylation of selected cysteine residues of EZH2 in ...
Malaria remains a major health challenge, with increasing resistance to frontline chemotherapy. Recent cheminformatics studies have revealed that potent antiplasmodials occupy a distinct antimalarial chemical space (AMCS), ...
Diabetes is a metabolic disorder of increasing global concern. Characterized by constantly elevated levels of glucose, severe β-cell dysfunction, and insulin resistance, it is the cause of a major burden on patients if not ...
In this work, novel 2-substituted-3-((1-substituted-1H-1,2,3-triazol-4-yl) methoxy) quinoxaline analogues were designed, synthesized, and various analytical techniques, viz., 1H NMR, 13C NMR, and Mass spectrometry, were ...
Neurological disorders remain a major challenge in modern medicine due to the brain’s complexity and the limited efficacy of genetic therapies. Acetylcholinesterase (AChE) is a key target in the treatment of Alzheimer’s ...
Breast cancer remains one of the major causes of cancer-related deaths in the world for women, which emphasizes the need for better treatment approaches. Conventional therapies target both cancerous as well as normal cells, ...
Polydatin (PD), a stilbenoid resveratrol-derivative in Vitaceae, Liliaceae, and Leguminosae, exhibits pharmacological protection in metabolic disorders. This study investigated Polydatin, as a potential pan-PPAR agonist ...
Pyrazinamide is a powerful sterilizing agent that reduces the treatment duration required to cure tuberculosis and works synergistically with both new and existing anti-tuberculosis drugs. Thirty-one derivatives of ...
Sarcopenia is a progressive and generalized loss of skeletal muscle and functions associated with ageing with currently no definitive treatment. Alterations in gut microbial composition have emerged as a significant ...
The liver and skeletal muscle are metabolically interconnected organs vital for maintaining systemic homeostasis. Arsenic toxicity is known to adversely affect both organs individually, yet the mechanistic link between ...
3-Acetyl-11-keto-β-boswellic acid (AKBA), a bioactive compound derived from Boswellia serrata, exhibits significant anti-inflammatory and antioxidant properties, making it a promising candidate for treating inflammatory ...
In this Letter, an extended pad packaged GaN HEMT-based biosensing system has been reported for the detection of US Food and Drug Administration-approved ubiquitin-C-terminal-hydrolase-L1 and glial fibrillary acidic protein ...
Parkinson’s disease (PD) poses a global menace, as the available treatment methods solely aim to mitigate symptoms. An effective strategy to address the pathogenesis of PD involves eliminating the accumulation of aggregated ...
Oxidative stress is one of the factors in Parkinson’s disease
(PD) etiology. Genes implicated in PD, such as DJ-1, PARKIN and PINK1,
contribute to oxidative stress, affecting dopaminergic neurons. The Xlinked
G6PD gene ...
Ayurveda is based on natural therapeutic methods that focuses on eliminating toxins from the body and enhancing both physical and mental regeneration using herbal remedies. Medicinal plants have significant elemental and ...
Given the need for innovative interventions for tackling the burden of TB, host directed therapies have emerged as a promising alternative in recent times. The combination of sertraline with frontline TB drugs has shown ...
Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by motor dysfunction and non-motor symptoms affecting cognition, mood and autonomic function. Both genetic susceptibility and environmental ...
Neurodegenerative disorders (NDDs), including Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), and Huntington’s disease (HD), are characterized by progressive neuronal loss leading ...
The work reports a meander-gated GaN HEMT-based biosensor for the noninvasive detection of the Scandinavian Neurotrauma Committee (SNC) recommended biomarker S100B in clinically relevant concentration ranges. The proposed ...
Cancer is one of the leading causes of death globally, with the reported numbers rising every year. Although the medical fraternity has made considerable progress in early detection and treatment interventions, the numbers ...