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Browsing BITS Faculty Publications by Author "Jindal, Anil B."

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Asymmetric lipid–polymer particles (LIPOMER) by modified nanoprecipitation: role of non-solvent composition

Jindal, Anil B. (Elsevier, 2015-07)

Asymmetric lipid polymer nanostructures (LIPOMER) comprising glyceryl monostearate (GMS) as lipid and Gantrez AN 119 (Gantrez) as polymer, revealed enhanced splenic accumulation. In the present paper, we attempt to explain ...
Bugs as Drugs: Understanding the Linkage between Gut Microbiota and Cancer Treatment

Jindal, Anil B. (Bentham Science, 2022)

The commensal microbiota is known to regulate host physiology. Dysbiosis or compromised resilience in the microbial ecology is related to the impending risk of cancer. A potential link between cancer and microbiota is ...
Compression

Jindal, Anil B. (Springer, 2023-07)

Compaction of powder involves compression and consolidation of the solids on the application of pressure. The forces involved in these processes play an important role in the design and development of solid oral dosage ...
Current status of dolutegravir delivery systems for the treatment of HIV-1 infection

Jindal, Anil B. (Elsevier, 2022-10)

According to the World Health Organization (WHO), an estimated 37.7 million people were living with HIV in 2020. Dolutegravir is recommended as the first line and second line antiretroviral drug for the treatment of HIV-1 ...
Current Status of Therapeutic Peptides for the Management of Diabetes Mellitus

Jindal, Anil B. (Springer, 2024-02)

Diabetes mellitus (DM) is a chronic endocrine disorder with lifelong implications. The prevalence of this condition is steadily increasing, emphasizing the need for effective management to maintain healthy blood sugar ...
Development and validation of reverse-phase high-performance liquid chromatographic (RP-HPLC) method for quantification of Efavirenz in Efavirenz-Enfuvirtide co-loaded polymer-lipid hybrid nanoparticles

Jindal, Anil B. (Elsevier, 2019-10)

The objective of present work was to develop rapid, sensitive, selective, accurate and precise RP-HPLC method for analysis of Efavirenz from combination anti-HIV drug (Efavirenz-Enfuvirtide) incorporated into polymer-lipid ...
Development of cationic Isometamidium chloride loaded long-acting lipid nanoformulation: optimization, cellular uptake, pharmacokinetics, biodistribution, and immunohistochemical evaluation

Jindal, Anil B. (Elsevier, 2021-12)

The aim of the present work involved the development and evaluation of long-acting Isometamidium chloride (ISMM)-Docusate sodium (DS) complex loaded lipid nanoparticles (LA ISMM-DS LNP). The development involved screening ...
Development of efavirenz loaded solid lipid nanoparticles: Risk assessment, quality-by-design (QbD) based optimisation and physicochemical characterisation

Jindal, Anil B. (Elsevier, 2017-06)

The purpose of this study was development and characterisation of efavirenz (EFZ) loaded solid lipid nanoparticles (SLN) using QbD approach. Quality target product profile of EFZ loaded SLN were defined and critical quality ...
Drying

Jindal, Anil B. (Springer, 2023-07)

Drying is a vital process in pharmaceutical formulation involving removal of moisture from solids by applying heat, thus resulting in both heat and mass transfer. The process when theoretically studied utilizes various ...
The effect of particle shape on cellular interaction and drug delivery applications of micro- and nanoparticles

Jindal, Anil B. (Elsevier, 2017-10)

Encapsulation of therapeutic agents in nanoparticles offers several benefits including improved bioavailability, site specific delivery, reduced toxicity and in vivo stability of proteins and nucleotides over conventional ...
Evaluation of Pharmacokinetics, Biodistribution, and Antimalarial Efficacy of Artemether-Loaded Polymeric Nanorods

Jindal, Anil B. (ACS, 2023)

Artemether oily injection is recommended for the treatment of severe malaria by the intramuscular route. The major limitations of the artemisinin combination therapy are erratic absorption from the injection site and high ...
Fabrication and evaluation of artemether loaded polymeric nanorods obtained by mechanical stretching of nanospheres

Jindal, Anil B. (Elsevier, 2021-08)

The objective of the present study was to prepare and evaluate artemether-loaded poly (lactic-co-glycolic acid) (PLGA) nanorods by mechanical stretching of nanospheres. Artemether-loaded PLGA nanospheres were prepared by ...
Fluid Bed Processing Technology

Jindal, Anil B. (Springer, 2023-07)

Fluid bed processing technology is widely used in the pharmaceutical industry for the processing of multiparticulates. The chapter describes the theory of fluidization followed by the components of a fluidized bed processor ...
Freeze-drying revolution: unleashing the potential of lyophilization in advancing drug delivery systems

Jindal, Anil B. (Springer, 2023-11)

Lyophilization also known as freeze-drying is a technique that has been employed to enhance the long-term durability of nanoparticles (NPs) that are utilized for drug delivery applications. This method is used to prevent ...
Implementing analytical quality by design in reversed phase-high performance liquid chromatography for simultaneous estimation of teriflunomide and quercetin: Applicability in dual drug loaded topical microemulsion

Jindal, Anil B. (Taylor & Francis, 2024-03)

The current study reports the development of a novel, robust, and sensitive reversed-phase high-performance liquid chromatography (RP-HPLC) method for the simultaneous estimation of teriflunomide (TFD) and quercetin (QCN) ...
In situ hybrid nano drug delivery system (IHN-DDS) of antiretroviral drug for simultaneous targeting to multiple viral reservoirs: An in vivo proof of concept

Jindal, Anil B. (Elsevier, 2017-04)

We report In situ hybrid nano drug delivery system (IHN-DDS) of nevirapine (NVP) for simultaneous targeting to multiple viral reservoirs. The IHN-DDS system was comprised of a preconcentrate containing NVP, lipid, and a ...
An insight into obtaining of non-spherical particles by mechanical stretching of micro- and nanospheres

Jindal, Anil B. (Elsevier, 2020-10)

Drug encapsulated nanoparticles offer several advantages, including site-specific delivery, improved solubility, stability, bioavailability with reduced toxicity. Besides the particle size, the shape of the particles also ...
Intracellular Delivery: An Overview

Jindal, Anil B. (Springer, 2019-11)

Targeted intracellular delivery is gaining importance, especially for improved therapy of cancer and intracellular infections. Endocytosis or cellular internalization, a physiological process for intracellular delivery of ...
Intranasal transmucosal drug delivery: An alternative approach to the parenteral route for medical emergencies

Jindal, Anil B. (Elsevier, 2023-05)

Medical emergencies such as insulin-induced hypoglycaemia, anaphylactic reactions, seizures and opioid induced respiratory depression, need to be treated as quickly as possible in order to prevent untoward life-threatening ...
Lipid Based Nanocarriers for Delivery of Anti-HIV Drugs: A Mini Review

Jindal, Anil B. (Bentham Science, 2018)

Introduction: At the end of 2014, almost 36.9 million people were living with HIV which has put the HIV infection in the list of major public health issues. Although almost thirty drugs are available for the treatment of ...

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