BITS Faculty Publications: Recent submissions

Now showing items 1-20 of 10507

Label-free GaN HEMT-based biosensing platform for interferon-γ detection

Taliyan, Rajeev (Elsevier, 2024-08)

Intracranial injury such as traumatic brain injury is caused by sudden injury to the brain from external mechanical force causing health loss and disability worldwide. The work reports the design and development of a GaN ...
Pharmacokinetic and Biodistribution Studies of Camel Milk Casein Nanoparticles Loaded Sorafenib in Swiss Albino Mice

Taliyan, Rajeev; Dubey, Uma S. (Springer, 2024-06)

Sorafenib, a multikinase inhibitor, is used for the treatment of advanced stages of hepatic and renal carcinoma patients. However, sorafenib’s low solubility, low bioavailability, unfavorable pharmacokinetic properties, ...
Immunological challenges and opportunities in glioblastoma multiforme: A comprehensive view from immune system lens

Singhvi, Gautam; Taliyan, Rajeev (Elsevier, 2024-11)

Glioblastoma multiforme (GBM), also known as grade IV astrocytoma, is the most common and deadly brain tumour. It has a poor prognosis and a low survival rate. GBM cells' immunological escape mechanism helps them resist ...
Neuroprotective potential of Epigenetic modulators, its regulation and therapeutic approaches for the management of Parkinson's disease

Taliyan, Rajeev (Elsevier, 2024-12)

The progressive degeneration of dopaminergic neurons in the substantia nigra region of the brain leads to a deficiency of dopamine and, ultimately, the onset of Parkinson's disease (PD). Since there is currently no cure ...
Millions of people worldwide are negatively impacted by a diverse range of brain conditions known as neurodegenerative diseases. The work reports a GaN HEMT-based biosensing system for the early detection and monitoring of neurodegenerative disease biomarkers in clinically relevant concentration ranges. The developed system offers a high sensitivity of 19.40 µA/pg/ml, 0.52 mA/pg/ml, 0.69 mA/ng/ml, 0.13 mA/pg/ml, 23.66 µA/pg/ml, and 23.85 µA/pg/ml for the detection of UCH-L1, GFAP, S100B, IL-6, Aβ, and IFN-γ respectively. The proposed biofunctionalization assay has an excellent specificity and selectivity, signal-to-noise ratio of 1:16, 1:23, and 1:38 for UCH-L1, GFAP, and S100B detection respectively with a LoD of 0.06 fg/ml. The platform has good repeatability with an average sensitivity of 19.41 µA/pg/ml, 0.524 mA/pg/ml, and 0.704 mA/ng/ml for UCH-L1, GFAP, and S100B detection respectively. The sensors have a very good shelf-life for a storage time of 35 days with reductions of 1.39 %, 1.72 %, and 2.05 % in sensor response and 2.88 %, 2.76 %, and 2.96 % in sensitivity for UCH-L1, GFAP, and S100B respectively. The coefficient of variation (CV) values for conventional and meander-gated GaN HEMT biosensors were found to be ∼0.038 and ∼0.026 respectively. A slight variation of ∼4.41 % in sensor response when the sensor was reused clearly demonstrates the sensor’s reusability. A very high resolution with detection capability in the ultra-low concentration of fg/ml with good linearity and quantifiable sensor response which is a key requirement for early-stage detection of diseases has been observed for sensor design with source-to-drain distance () of 10 µm. Thus, the platform capability and suitability for early detection and prognosis of neurodegenerative disease detection and monitoring have been demonstrated. Further, the system can be imperative in patient screening in clinical, sports, and warfare for CT or MRI scan requirements.

Taliyan, Rajeev (Elsevier, 2025-01)

Psychiatric disorders pose a significant global health challenge, exacerbated by the COVID-19 pandemic and insufficiently addressed by the current treatments. This review explores the emerging role of bile acids and the ...
Neurodegenerative diseases early detection and monitoring system for point-of-care applications

Taliyan, Rajeev (Elsevier, 2025-01)

Millions of people worldwide are negatively impacted by a diverse range of brain conditions known as neurodegenerative diseases. The work reports a GaN HEMT-based biosensing system for the early detection and monitoring ...
Design aspects, development, and sensitivity analysis of gan hemt-based biosensing platform for label-free detection of interleukin-6

Taliyan, Rajeev (IOP, 2025)

Severe TBI survivors face long-term brain damage requiring accurate diagnosis and early treatment as the therapeutic time window typically ranges from minutes to hours before the secondary injury. In this work, we report ...
Chitinase-3-like-1: a multifaceted player in neuroinflammation and degenerative pathologies with therapeutic implications

Taliyan, Rajeev (Springer, 2025-01)

Chitinase-3-like-1 (CHI3L1) is an evolutionarily conserved protein involved in key biological processes, including tissue remodeling, angiogenesis, and neuroinflammation. It has emerged as a significant player in various ...
Kynurenine monooxygenase inhibition and associated reduced quinolinic acid reverses depression-like behaviour by upregulating Nrf2/ARE pathway in mouse model of depression: In-vivo and In-silico studies

Khare, Pragyanshu (Elsevier, 2022-09)

Kynurenine pathway, a neuroimmunological pathway plays a substantial role in depression. Consistently, increased levels of neurotoxic metabolite of kynurenine pathway; quinolinic acid (QA) found in the suicidal patients ...
Topical menthol, a pharmacological cold mimic, induces cold sensitivity, adaptive thermogenesis and brown adipose tissue activation in mice

Khare, Pragyanshu (Wiley, 2024-07)

Brown adipose tissue (BAT) thermogenesis has profound energy-expanding potential, which makes it an attractive target tissue to combat ever-increasing obesity and its other associated metabolic complications. Although it ...
The TRPC5 receptor as pharmacological target for pain and metabolic disease

Khare, Pragyanshu (Elsevier, 2024-11)

The transient receptor potential canonical (TRPC) channels are a group of highly homologous nonselective cation channels from the larger TRP channel family. They have the ability to form homo- and heteromers with varying ...
Nanoparticle-based materials for wound management

Pandey, Murali Monohar (Elsevier, 2024)

Nanotechnology is an approach where nanoscale materials are biomedically used for the prevention of various diseases and infections. Their smaller size and larger surface area make them appropriate for various applications. ...
In situ bioprinting: process, bioinks, and applications

Pandey, Murali Monohar (ACS, 2024-04)

Traditional tissue engineering methods face challenges, such as fabrication, implantation of irregularly shaped scaffolds, and limited accessibility for immediate healthcare providers. In situ bioprinting, an alternate ...
Oxidized ionic polysaccharide hydrogels: review on derived scaffolds characteristics and tissue engineering applications

Pandey, Murali Monohar (Elsevier, 2024-11)

Polysaccharide-based hydrogels have gained prominence due to their non-toxicity, biocompatibility, and structural adaptability for constructing tissue engineering scaffolds. Polysaccharide crosslinking is necessary for ...
Acetylcholine structure-based small activatable fluorogenic probe for specific detection of acetylcholinesterase

Sidhu, Jagpreet Singh (ACS, 2023-05)

Early detection of Alzheimer’s disease (AD) is important for taking proper measures against AD pathogenesis. Acetylcholinesterase (AChE) is widely reported to be associated with the pathogenicity of AD. Here, employing the ...
Unraveling the Conversion of Fatty Acids into Terminal Alkenes by an Integral Membrane Enzyme, UndB

Sidhu, Jagpreet Singh (ACS, 2023-11)

Biosynthetically produced 1-alkenes hold immense value as green alternatives to fossil fuels and find widespread applications in the polymer, lubricant, and detergent industries. UndB is the only known membrane enzyme ...
Phenoxy-1,2-dioxetane-based activatable chemiluminescent probes: tuning of photophysical properties for tracing enzymatic activities in living cells

Sidhu, Jagpreet Singh; Taliyan, Rajeev (RSC, 2024-11)

The use of chemiluminophores for tracing enzymatic activities in live-cell imaging has gained significant attention, making them valuable tools for diagnostic applications. Among various chemiluminophores, the phenoxy-1, ...
Investigation of antibacterial potential of Natsiatum herpeticum Buch.-Ham. ex Arn. using in silico-in vitro approach

Jadhav, Hemant R. (Elsevier, 2024-01)

Since ages, natural products have laid the foundation for the development of promising antimicrobials. With the advent of antimicrobial resistance, the search for effective antimicrobials continues as its shortfall will ...
Unveiling the potential of novel indol-3-yl-phenyl allylidene hydrazine carboximidamide derivatives as AChE/BACE 1 dual inhibitors: a combined in silico, synthesis and in vitro study

Jadhav, Hemant R. (RSC, 2024-07)

Alzheimer's disease (AD) is a complex and debilitating neurological disorder that primarily affects the brain, leading to cognitive decline and memory loss. AD is a chronic and progressive disease that gradually impairs ...
Design, synthesis, in silico, and in vitro evaluation of pyrrol-2-yl-phenyl allylidene hydrazine carboximidamide derivatives as AChE/BACE 1 dual inhibitors

Jadhav, Hemant R. (RSC, 2024-08)

Alzheimer's disease (AD) manifests as a progressive decline in cognitive function and mental behavior. Targeting two crucial enzymes associated with AD, acetylcholinesterase (AChE) and BACE 1 (Beta-site APP Cleaving Enzyme), ...

Now showing items 1-20 of 10507

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