BITS Faculty Publications: Recent submissions

Now showing items 1941-1960 of 10939

Silent metabolism and not-so-silent biological activity: possible molecular mechanisms of stress response in edible desert legumes

Sharma, Pankaj Kumar; Deepa, P.R. (Springer, 2021-11)

In the arid/semi-arid regions of India, there are many legumes often growing in the wild like Prosopis cineraria, Cyamopsis tetragonoloba and Acacia senegal. These legumes accumulate useful metabolites, often as glycosides, ...
Desert legume Prosopis cineraria as a novel source of antioxidant flavonoids / isoflavonoids: Biochemical characterization of edible pods for potential functional food development

Deepa, P. R.; Sharma, Pankaj Kumar (Elsevier, 2022-03)

Flavonoids and isoflavonoids in foods are attracting attention as they are significant antioxidant and phytoestrogenic compounds that are beneficial for human health. In this study, the edible pods of the underutilized ...
Effect of different proportions of phenolics on antioxidant potential: Pointers for bioactive Synergy/Antagonism in foods and nutraceuticals

Sharma, Pankaj Kumar; Deepa, P.R. (Springer, 2022-07)

Phenolic compounds include a broad variety of antioxidant plant substances such as flavonoids that have in common an aromatic ring with one or more hydroxyl groups. Nutraceuticals and health food supplements are designed ...
COVID-19 infection and metabolic comorbidities: Mitigating role of nutritional sufficiency and drug – nutraceutical combinations of vitamin D

Deepa, P. R.; Tare, Meghana (Elsevier, 2023-03)

The vulnerability of human health is amplified in recent times with global increase in non-communicable diseases (due to lifestyle changes and environmental insults) and infectious diseases (caused by newer pathogens and ...
In silico and in vitro analysis of PPAR – α / γ dual agonists: Comparative evaluation of potential phytochemicals with anti-obesity drug orlistat

Deepa, P.R.; Sharma, Pankaj Kumar; Murugesan, Sankaranarayanan (Elsevier, 2022)

Obesity is an abnormal fat accumulation disorder in the metabolic syndrome constellation, and a risk factor for diabetes, cardiovascular disorders, non-alcoholic fatty liver disease (NAFLD), and cancer. Nuclear receptors ...
Nutraceutical and flavor profiles in underutilized desert legumes of India: gene editing strategies towards sustainable food development

Joshi, Mukul; Deepa, P. R.; Sharma, Pankaj Kumar (Springer, 2023-03)

Climate change has posed a challenge for food security all over the world in the form of fluctuating crop yields and novel disease outbreaks in plants. Human society’s overdependence on a few food crops does not seem a ...
Investigating the antioxidant activity enhancer effect of Cyamopsis tetragonoloba seed extract on phenolic phytochemicals

Sharma, Pankaj Kumar; Deepa, P. R. (Frontiers, 2023-03)

Phenolic phytochemicals are known for antioxidant-mediated pharmacological effects in various diseases (diabetes, cancer, CVDs, obesity, inflammatory and neurodegenerative disorders). However, individual compounds may not ...
Targeting lipid-sensing nuclear receptors PPAR (α, γ, β/δ): HTVS and molecular docking/dynamics analysis of pharmacological ligands as potential pan-PPAR agonists

Deepa, P.R.; Sharma, Pankaj Kumar; Murugesan, Sankaranarayanan (Springer, 2023-06)

The global prevalence of obesity-related systemic disorders, including non-alcoholic fatty liver disease (NAFLD), and cancers are rapidly rising. Several of these disorders involve peroxisome proliferator-activated receptors ...
Targeting lipid metabolism in plants for non-animal sources of nutraceuticals towards sustainable food production and scale up

Deepa, P.R. (Elsevier, 2023-10)

With the growing demand for nutraceuticals, there is renewed interest in tapping different resources, preferably from non-animal sources. This review discusses two major nutraceuticals, vitamin D and essential fatty acids ...
Development and Characterization of Cold Atmospheric Pressure Plasma Jet Source for Skin Wound Healing Application

Deepa, P.R. (IEEE, 2023)

Cold atmospheric pressure plasma jet (C-APPJ) sources are gaining much attention due to extraordinary capability of delivering the reactive oxygen and nitrogen species (RONS) in a wide range of operating parameters. Much ...
A clustering and graph deep learning-based framework for COVID-19 drug repurposing

Agarwal, Vinti; Deepa, P.R. (Elsevier, 2024-09)

Drug repurposing (or repositioning) is the process of finding new therapeutic uses for drugs already approved by drug regulatory authorities (e.g., the Food and Drug Administration (FDA) and Therapeutic Goods Administration ...
Comparative bioactivity assessment of bixin pigment and associated phytochemicals extracted from annatto seeds using conventional and green solvents

Sharma, Pankaj Kumar; Deepa, P.R. (JFDA, 2024-06)

Nutraceuticals, that include food ingredients and bioactives from natural products, confer physiological health benefits and protection against chronic diseases. Annatto is a tropical shrub grown in Central and South America ...
Nontoxic Aggregation-Induced Emissive Luminogen for the Detection of Amyloid Fibrils and Cellular Protein Aggregates

Chowdhury, Rajdeep; Addy, Partha Sarathi (ACS, 2023-10)

Protein misfolding and aggregation resulting in amyloid formation is directly linked to various diseases. Hence, there is keen interest in developing probes for the selective detection of such misfolded aggregated proteins. ...
Photodynamic Therapy Induced Mitochondrial Targeting Strategies for Cancer Treatment: Emerging Trends and Insights

Chowdhury, Rajdeep; Singhvi, Gautam (ACS, 2024-02)

The perpetuity of cancer prevalence at a global level calls for development of novel therapeutic approaches with improved targetability and reduced adverse effects. Conventional cancer treatments have a multitude of ...
Nesting sites of birds and spiders in the semi-arid zone of Rajasthan, India

Marathe, Sandhya (Current Science, 2018-05)
The phylogenomics of CRISPR-Cas system and revelation of its features in Salmonella

Marathe, Sandhya (Springer Nature, 2020-12)

Salmonellae display intricate evolutionary patterns comprising over 2500 serovars having diverse pathogenic profiles. The acquisition and/or exchange of various virulence factors influences the evolutionary framework. To ...
The Nobel Prize in Chemistry 2020: Celebrating the collaborative efforts leading to a tool (CRISPR-Cas) for rewriting a code of life

Marathe, Sandhya (Current Science, 2020-11)

The Nobel Prize in Chemistry 2020 has been awarded to Emmanuelle Charpen- tier, from the Max Planck Unit for the Science of Pathogens, Berlin, Germany and Jennifer A. Doudna, from University of California, Berkeley, ...
The CRISPR-Cas system differentially regulates surface-attached and pellicle biofilm in salmonella enterica serovar typhimurium

Marathe, Sandhya Amol (ASM Journals, 2022-06)

The CRISPR-Cas mediated regulation of biofilm by Salmonella enterica serovar Typhimurium was investigated by deleting CRISPR-Cas components ΔcrisprI, ΔcrisprII, ΔΔcrisprI crisprII, and Δcas op. We determined that the system ...
Direct saponification of wet microalgae by methanolic potassium hydroxide using acetone as co-solvent

Verma, Sanjay Kumar (Elsevier, 2019-02)

The fatty acids of microalgae are promising source of biodiesel and omega-3 fatty acids. The objective of this study is extraction of fatty acids from wet Dunaliela salina by direct saponification using methanolic potassium ...
Antimicrobial Haplindole Alkaloids as Chemical Marker for Rapid Identification of Stigonematales (Cyanobacteria)

Verma, Sanjay Kumar (Taylor & Francis, 2020-12)

Antimicrobial Hapalindole alkaloids have been identified in the order Stigonematales. Being exclusively present in a few members of this order, they can easily serve as a good chemical marker for their identification. In ...

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