BITS Faculty Publications: Recent submissions

Now showing items 5281-5300 of 12372

Leishmaniasis is the most widespread pathogenic disease in several countries. Currently, no effective vaccines are available, and the control of Leishmaniasis primarily relies on decade-old chemotherapy. The treatment for the Leishmaniasis is not up to the mark. Current therapy for Leishmaniasis is ancient and requires hospitalization for the administration. These medications are also highly toxic and resistant. β-carboline, a natural indole containing alkaloid, holds a vital position in the field of medicinal chemistry with a diversified pharmacological action. The current review focuses mainly on the anti-leishmanial effects of β-carboline analogs and their synthetic strategies, structural activity relationship studies (SAR). The past ten years alterations unveiled by β-carboline analogs present in phytoconstituents and various derivatives of synthesized analogs with the mechanism of action were briefly shortlisted and illustrated

Murugesan, Sankaranarayanan (Bentham Science, 2020)

Psoralen or furocoumarin is a linear three ring heterocyclic compound. Psoralens are planar, tricyclic compounds, consisting of a furan ring fused to a coumarin moiety. Psoralen has been known for a wide spectrum of ...
Review article| Volume 6, ISSUE 9, e04916, September 2020 PDF [2 MB] Figures Save Share Reprints Request Recent evolution on synthesis strategies and anti-leishmanial activity of β-carboline derivatives – An update

Murugesan, Sankaranarayanan (Elsevier, 2020-09)

Leishmaniasis is the most widespread pathogenic disease in several countries. Currently, no effective vaccines are available, and the control of Leishmaniasis primarily relies on decade-old chemotherapy. The treatment for ...
Coumarin-Oxadiazole Derivatives: Synthesis and Pharmacological Properties

Murugesan, Sankaranarayanan (Bentham Science, 2020)

Coumarin and oxadiazole moieties ubiquitously occur in a wide range of natural products and are valued for their varied and beneficial pharmacological activities. Herein, this review focuses on various documented techniques ...
Synthesis, biological evaluation, molecular docking, molecular dynamics and DFT studies of quinoline-fluoroproline amide hybrids

Murugesan, Sankaranarayanan (Elsevier, 2020-10)

Three analogs of quinoline hybrid 4-cis-fluoro-proline amides (QHCFPAs) were synthesized and characterized using spectroscopic techniques like 1H NMR, 13C NMR, DEPT 135, FT-IR and ESI-MS. The in vitro antidiabetic activity ...
Design, synthesis, in silico studies, and evaluation of novel chalcones and their pyrazoline derivatives for antibacterial and antitubercular activities

Murugesan, Sankaranarayanan (Springer, 2020-07)

A new series of naphthyl chalcones (3a–3p) and their pyrazoline derivatives (4a–4h) were synthesized using substituted acetophenones, substituted naphthaldehydes, and hydrazine hydrate as starting materials. All the ...
Druggable targets of SARS-CoV-2 and treatment opportunities for COVID-19

Murugesan, Sankaranarayanan (Elsevier, 2020-11)

COVID-19 caused by the novel SARS-CoV-2 has been declared a pandemic by the WHO is causing havoc across the entire world. As of May end, about 6 million people have been affected, and 367 166 have died from COVID-19. Recent ...
Sequential multicomponent catalytic synthesis of pyrrole-3-carboxaldehydes: Evaluation for antibacterial and antifungal activities along with docking studies

Murugesan, Sankaranarayanan (RSC, 2020)

A sequential multicomponent synthesis of highly substituted pyrrole-3-carboxaldehydes has been developed under metal-free conditions. This one-pot protocol involves proline-catalyzed direct chemoselective Mannich ...
Seeking potent anti-tubercular agents: design and synthesis of substituted-N-(6-(4-(pyrazine-2-carbonyl)piperazine/homopiperazine-1-yl)pyridin-3-yl)benzamide derivatives as anti-tubercular agents

Murugesan, Sankaranarayanan (RSC, 2020)

Pyrazinamide is an important first-line drug used in shortening TB therapy. In our current work, a series of novel substituted-N-(6-(4-(pyrazine-2-carbonyl)piperazine/homopiperazine-1-yl)pyridin-3-yl)benzamide derivatives ...
Search for new therapeutics against HIV-1 via dual inhibition of RNase H and integrase: current status and future challenges

Murugesan, Sankaranarayanan (Future Science Group, 2021-01)

Reverse transcriptase and integrase are key enzymes that play a pivotal role in HIV-1 viral maturation and replication. Reverse transcriptase consists of two active sites: RNA-dependent DNA polymerase and RNase H. The ...
Design, synthesis and evaluation of novel β-carboline ester analogues as potential anti-leishmanial agents

Murugesan, Sankaranarayanan (Taylor & Francis, 2021-09)

Leishmaniasis is one of today's most neglected diseases. The emergence of new anti-leishmanial therapies emphasizes several study groups funded by the World Health Organization. The present investigation will focus on the ...
1,2,3,4-Tetrahydroisoquinoline (THIQ) as privileged scaffold for anticancer de novo drug design

Murugesan, Sankaranarayanan (Taylor & Francis, 2021-04)

Cancer is a dreadful disorder that is emerging as one of the leading causes of mortality across the globe. The complex tumor environment, supplemented with drawbacks of the existing drugs, has made it a global health ...
Pharmacoinformatics-based investigation of bioactive compounds of Rasam (South Indian recipe) against human cancer

Murugesan, Sankaranarayanan (Springer, 2021-11)

Spice-rich recipes are referred to as “functional foods” because they include a variety of bioactive chemicals that have health-promoting properties, in addition to their nutritional value. Using pharmacoinformatics-based ...
Novel phenanthridine amide analogs as potential anti-leishmanial agents: In vitro and in silico insights

Murugesan, Sankaranarayanan (Elsevier, 2021-12)

In the current work, sixteen novel amide derivatives of phenanthridine were designed and synthesized using 9-fluorenone, 4-Methoxy benzyl amine, and alkyl/aryl acids. The characterization of the title compounds was performed ...
Identification of Papain-Like Protease inhibitors of SARS CoV-2 through HTVS, Molecular docking, MMGBSA and Molecular dynamics approach

Murugesan, Sankaranarayanan (Elsevier, 2022-12)

Coronaviruses (CoVs) are a large group of enveloped positive sense single-stranded RNA viruses that can cause disease to humans. These are zoonotic having potential to cause large-scale outbreaks of infections widely causing ...
Medicinal chemistry perspectives of 1,2,3,4-tetrahydroisoquinoline analogs – biological activities and SAR studies

Murugesan, Sankaranarayanan (RSC, 2021)

Isoquinoline alkaloids are a large group of natural products in which 1,2,3,4-tetrahydroisoquinolines (THIQ) form an important class. THIQ based natural and synthetic compounds exert diverse biological activities against ...
Pharmacophore based virtual screening, molecular docking, molecular dynamics and MM-GBSA approach for identification of prospective SARS-CoV-2 inhibitor from natural product databases

Murugesan, Sankaranarayanan (Taylor & Francis, 2020-09)

COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily appeared in Wuhan, China, in December 2019. At present, no proper therapy and vaccinations are available for the disease, and it is ...
Novel thiophene Chalcones-Coumarin as acetylcholinesterase inhibitors: Design, synthesis, biological evaluation, molecular docking, ADMET prediction and molecular dynamics simulation

Murugesan, Sankaranarayanan (Elsevier, 2022-02)

A series of around eight novel chalcone based coumarin derivatives (23a-h) was designed, subjected to in-silico ADMET prediction, synthesized, characterized by IR, NMR, Mass analytical techniques and evaluated as ...
Design, synthesis and structure–activity relationship studies of novel spirochromanone hydrochloride analogs as anticancer agents

Murugesan, Sankaranarayanan (Future Science Group, 2022-01)

Literature reports suggest spirochromanone derivatives exhibit anticancer activity. Methodology: The authors designed and synthesized 18 spirochromanone derivatives (Csp 1–18). The compounds were characterized and evaluated ...
In-vivo and in-silico toxicity studies of daidzein: an isoflavone from soy

Murugesan, Sankaranarayanan (Taylor & Francis, 2020-10)

Daidzein is a naturally occurring compound belonging to the class isoflavones and found in soya beans and other legumes. Acute oral toxicity was performed as per OECD guideline (TG 423) with slight modifications. A repeated ...
One-Pot Synthesis of Novel Hydrazono-1,3-Thıazolıdın-4-One Derivatives as Anti-HIV and Anti-Tubercular Agents: Synthesıs, Bıologıcal Evaluatıon, Molecular Modelling and Admet Studıes

Murugesan, Sankaranarayanan (Bentham Science, 2022)

The necessity for newer anti-HIV and anti-tubercular medications has arisen as a result of the prevalence of opportunistic infections caused by HIV (human immunodeficiency virus). Objective: A series of ten new hydrazono ...

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